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Clin Colon Rectal Surg 2018; 31(03): 179-191
DOI: 10.1055/s-0037-1602238
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Emerging Systemic Therapies for Colorectal Cancer

Christine M. Veenstra
1   Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
,
John C. Krauss
1   Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
› Author Affiliations
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Publication History

Publication Date:
01 April 2018 (online)

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Abstract

Despite advances over the past 20 years in colorectal cancer (CRC) screening, diagnosis, and treatment, survival outcomes remain suboptimal. Five-year survival for patients with locally advanced CRC is 69%; 5-year survival drops to 12% for patients with metastatic disease. Novel, effective systemic therapies are needed to improve long-term outcomes. In this review, we describe currently available systemic therapies for the treatment of locally advanced and metastatic CRC and discuss emerging therapies, including encouraging advances in identifying novel targeted agents and exciting responses to immunotherapeutic agents.

Keywords

colorectal cancer - emerging therapies - targeted therapy - immunotherapy - clinical trials
 

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