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Nervenheilkunde 2014; 33(10): 720-722
DOI: 10.1055/s-0038-1627733
Therapieempfehlung
Schattauer GmbH

Pharmakologische Behandlung von Borderline-Persönlichkeitsstörungen

Empfehlung der Gesellschaft zur Erforschung und Therapie von Persönlichkeitsstörungen e. V.Pharmacotherapy of BorderlinePersonality Disorder
K. Lieb
1   Klinik für Psychiatrie und Psychotherapie Universitätsmedizin Mainz
,
J. Stoffers
1   Klinik für Psychiatrie und Psychotherapie Universitätsmedizin Mainz
,
B. Dulz
2   Klinik für Persönlichkeits- und Traumafolgestörungen, Asklepios Klinik Nord – Ochsenzoll, Hamburg
› Author Affiliations
Further Information

Publication History

eingegangen am: 02 May 2014

angenommen am: 20 June 2014

Publication Date:
24 January 2018 (online)

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Zusammenfassung

In den vergangenen Jahrzehnten wurden mehr als 30 randomisiert kontrollierte Therapiestudien zur pharmakotherapeutischen Behandlung der Borderline-Persönlichkeitsstörung publiziert. Dies ist mehr als bei jeder anderen Persönlichkeitsstörung, aber wenig im Vergleich zu anderen Erkrankungen wie etwa Depressionen und Schizophrenien. Daher geben die hier dargestellten Empfehlungen zur Pharmakotherapie nur einen groben Orientierungsrahmen. Kein Medikament ist zur Therapie zugelassen, und Psychotherapie sollte grundsätzlich bevorzugt werden. Dennoch kann eine Therapie mit Stimmungsstabilisierern und ggf. Antipsychotika der 2. Generation einzelne psychopathologische Symptome, z. B. Impulsivität oder Schwierigkeiten in der Kontrolle von Wut und Ärger positiv beeinflussen. Medikamente sollten kurzfristig und mit klaren Zielen verordnet werden. Polypharmazie ist wenn immer möglich zu vermeiden.

Summary

More than 30 randomised controlled studies investigating the pharmacotherapy of Borderline Personality Disorder have been published in the last decades. This is more compared to other forms of personality disorders, however little as compared to other psychiatric conditions such as depression and schizophrenia. The following recommendations can therefore propose only a rough framework for the pharmacotherapy of Borderline Personality Disorder. No drug is approved for therapy of this condition, and psychotherapy should be preferred. Nevertheless, mood stabilizers and certain second generation antipsychotics may help in controlling e. g. impulsive behaviour and outbursts of rage and anger. Drugs should only be prescribed for short periods of time and with defining clear goals. Polypharmacy should be avoided whenever possible.

Schlüsselwörter

Borderline-Persönlichkeitsstörung - Pharmakotherapie - randomisiert kontrollierte Studie - Metaanalyse

Keywords

Borderline Personality Disorder - pharmacotherapy - randomised controlled study - metaanalysis
 

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