Thromb Haemost 1989; 61(03): 540
DOI: 10.1055/s-0038-1646635
Letter to the Editor
Schattauer GmbH Stuttgart

Importance for Blood Anticoagulant Activity of a 2-Sulfate Grou on L-Iduronic Acid Residues in Heparin

R Rej
Department of Chemistry, McGill University, Montreal, PQ H3A 2A7, Canada
,
M Jaseja
Department of Chemistry, McGill University, Montreal, PQ H3A 2A7, Canada
,
A S Perlin
Department of Chemistry, McGill University, Montreal, PQ H3A 2A7, Canada
› Author Affiliations
Further Information

Publication History

Received 21 December 1988

Accepted after revision 09 March 1989

Publication Date:
24 July 2018 (online)

 
  • References

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  • 2 Casu B, Petitou M, Provasoli M, Sinay P. Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans. Trends Biochem Sci 1988; 13: 20-25
  • 3 Petitou M, Lormeau JC, Choay J. AT III binding site of heparin. Determination of the role of sulfate groups at the reducing-end disaccharide through new synthetic pentasaccharides Thromb Haemostas 1987; 58: 7 (Abstr)
  • 4 Van Boeckel CA A, Basten JE M, Lucas H, van Aelst SF. A synthetic heparin-like compound which still activates antithrombin III although it contains an open chain fragment instead of α-L-idopyranuronate. Angew Chem Int Ed Engl 1988; 27: 1177-1178
  • 5 Turvey JR. Sulfates of the simple sugars. Adv Carbohydr Chem 1966; 20: 183-218