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Clin Colon Rectal Surg 2023; 36(02): 138-145
DOI: 10.1055/s-0042-1760675
Review Article

Preparing the Bowel (Microbiome) for Surgery: Surgical Bioresilience

Heidi Paine
1   Division of General Surgery, Imperial College Healthcare NHS Trust, London, United Kingdom
,
Faye Jones
2   Division of General Surgery, King Edward VII Hospital, London, United Kingdom
,
James Kinross
3   Division of Colorectal Surgery, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Abstract

The preparation of the bowel for radical surgery is a corner stone of elective colorectal practice. The evidence for this intervention is of variable quality and it is often contradictory, yet there is now a global move toward the adoption of oral antibiotic therapy for the reduction of perioperative infective complications, such as surgical site infections. The gut microbiome is a critical mediator of the systemic inflammatory response to surgical injury, wound healing, and perioperative gut function. The loss of critical microbial symbiotic functions caused by bowel preparation and surgery has an adverse impact on surgical outcomes, yet the mechanisms through which this occurs are poorly defined. In this review, the evidence for bowel preparation strategies is critically appraised in the context of the gut microbiome. The impact of antibiotic therapy on the surgical gut microbiome and the importance of the intestinal “resistome” to surgical recovery is described. Data to support the augmentation of the microbiome through diet, probiotic and symbiotic approaches, as well as fecal transplantation are also appraised. Finally, we propose a novel strategy of bowel preparation defined as “surgical bioresilience” and define areas or prioritization in this emerging field. This describes the optimization of surgical intestinal homeostasis and core surgical exposome-microbiome interactions that regulate the wound immune microenvironment, the systemic inflammatory response to surgical injury, and gut function across the perioperative time course.

Keywords

bowel preparation - gut microbiome - surgical resistome - bioresilience

Supplementary Material



Publication History

Article published online:
03 February 2023

© 2023. Thieme. All rights reserved.

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