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Horm Metab Res 1981; 13(1): 53-55
DOI: 10.1055/s-2007-1019166
© Georg Thieme Verlag, Stuttgart · New York

Stimulation of Calcitonin Secretion Rate by 25,26-Dihydroxycholecalciferol in Vitamin D-Depleted Pigs

A. D. Care, D. W. Pickard, R. Ross, J. M. Garel1 , J. Redel2
  • Department of Animal Physiology and Nutrition, University of Leeds, Leeds, United Kingdom
  • 1Developmental Physiology Laboratory, P. and M. Curie University, Paris, France
  • 2Institute of Rheumatology, Hôpital Cochin, Paris, France
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Publication History

1979

1980

Publication Date:
14 March 2008 (online)

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Summary

The thyroid gland was surgically isolated in situ in young, vitamin D-depleted pigs and perfused with autologous blood under controlled conditions. The thyroid venous blood was quantitatively collected and the calcitonin (CT) concentration measured by radioimmunoassay. The addition of 25R,26-dihydroxycholecalciferol (25R,26-(OH)2D3), 25S,26-(OH)2D3 or 25RS,26-(OH)2D3) to the perfusing blood to raise the concentration by 0.65 to 10.0 ng/ml caused a significant increase in the secretion rate of CT.

Key-Words:

Calcitonin Secretion - 25,26-Dihydroxychole-calciferol - Calcium Homeostasis

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