Neuropediatrics 1998; 29(1): 40-42
DOI: 10.1055/s-2007-973532
Short communications

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Detection of Subclinical Central Nervous System Abnormalities in Two Patients with Mucolipidosis III by the Use of Motor and Somatosensory Evoked Potentials

E. Toscano1 , Anna Perretti2 , P. Balbi3 , Eufrasia Silvestro1 , G. Andria1 , G. Parenti1
  • 1Department of Pediatrics, Università degli Studi di Napoli "Federico II", via S. Pansini, Naples
  • 2Department of Neurological Sciences, Università degli Studi di Napoli "Federico II", via S. Pansini, Naples
  • 3Department of Rehabilitation, Medical Center of Campoli M. T., "Umberto Maugeri" Foundation, IRCCS, Benevento, Italy
Further Information

Publication History

Publication Date:
12 March 2007 (online)

Abstract

We have studied motor, somatosensory, brainstem auditory and visual evoked potentials in two patients with ML III without overt neurologic symptoms. Both our patients showed abnormal central motor fuctions upon magnetic cortical stimulation; in addition, in one of them, we observed a decreased conduction velocity of the nervous impulse in the central tract of the upper limb somatosensory pathway, from the cervical spinal cord to sensory cortex. Our results suggest that central motor pathways are affected in both children and also that the central somatosensory system is involved in one of them. We propose that the electrophysiological techniques might be of help to detect, locate and monitor minimal neurological lesions of mild lysosomal disorders like ML III.