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Journal of Pediatric Neurology 2012; 10(01): 001-005
DOI: 10.3233/JPN-2012-0533
Georg Thieme Verlag KG Stuttgart – New York

Transmission disequilibrium test and haplotype analysis of the MCP-1 –2518G/A polymorphism with Tourette syndrome in Chinese Han trios

Meijian Wang
a   Department of Biology, Medical School, Qingdao University, Qingdao, China
,
Yingying Yin
b   Department of Psychiatry, Medical College, Qingdao University, Qingdao, China
,
Wei Ren
c   Shandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
d   Institute of Clinical Research, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
,
Xiuhai Wang
a   Department of Biology, Medical School, Qingdao University, Qingdao, China
,
Shiguo Liu
c   Shandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
d   Institute of Clinical Research, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
e   Genetic Laboratory, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
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Publication History

19 April 2011

12 July 2011

Publication Date:
30 July 2015 (online)

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Abstract

The purpose of this study was to investigate the association between MCP-1 –2518G/A polymorphism and Tourette syndrome (TS) in Chinese Han population. We collected 324 Chinese Han individuals from 108 TS nuclear families from Chinese Han population and employed polymerase chain reaction and restriction enzyme digestion for determining the genotype of MCP-1 –2518G/A polymorphism. The data were analyzed using the transmission disequilibrium test, the genotype haplotype relative risk and haplotype-based haplotype relative risk. No biases were observed in the transmission of either of the two alleles (χ2 = 0.016, df=1, P = 0.898) to the affected probands in the total sample. The analyses of transmission disequilibrium test, haplotype relative risk and haplotype-based haplotype relative risk did not indicate any associations at MCP-1 –2518G/A with TS. Our results suggest that MCP-1 –2518G/A is not associated with susceptibility of Tourette syndrome in Chinese Han population.

Keywords

Tourette syndrome - MCP-1 - transmission disequilibrium test - haplotype relative risk