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Planta Med 2013; 79(18): 1775-1780
DOI: 10.1055/s-0033-1351075
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

A New Bis-Labdanic Diterpene from the Rhizomes of Alpinia pahangensis

Yasodha Sivasothy
1   Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia
,
Halijah Ibrahim
2   Institute of Biological Sciences, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia
,
Audra Shaleena Paliany
2   Institute of Biological Sciences, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia
,
Siti Aisyah Alias
2   Institute of Biological Sciences, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia
,
Nurur Raudzah Md Nor
3   Chemistry Department, Center of Foundation Studies, International Islamic University Malaysia, Selangor, Malaysia
,
Khalijah Awang
1   Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia
› Author Affiliations
Further Information

Publication History

received 12 June 2013
revised 03 October 2013

accepted 19 October 2013

Publication Date:
19 December 2013 (online)

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Abstract

The rhizomes of Alpinia pahangensis yielded a new bis-labdanic diterpene for which the name pahangensin C (1) was proposed along with twelve known analogues (2–13). The structure of 1 was elucidated via spectroscopic methods including 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Compounds 2 and 12 were isolated for the first time from the genus Alpinia. This is the second occurrence of compounds 2 and 12 in the Zingiberaceae family. Selected analogues exhibited moderate to strong inhibitory activity against Staphylococcus aureus and Bacillus cereus.

Key words

Alpinia pahangensis - Zingiberaceae - bis-labdanic diterpene - labdane diterpene - pahangensin C

Supporting Information

 

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