Complement-Modulating Properties of a Kaempferol 7-O-Rhamnosylsophoroside from the Leaves of Morinda morindoides

Kanyanga Cimanga; Tess de Bruyne; Bart Van Poel; Yuliang Ma; Magda Claeys; Luc Pieters; Kabangu Kambu; Lutete Tona; Phongi Bakana; Dirk Vanden Berghe; Arnold J. Vlietinck

doi:10.1055/s-2006-957657

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Planta Med 1997; 63(3): 220-223
DOI: 10.1055/s-2006-957657

Papers

Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Complement-Modulating Properties of a Kaempferol 7-O-Rhamnosylsophoroside from the Leaves of Morinda morindoides

Kanyanga Cimanga¹ , Tess de Bruyne¹ , Bart Van Poel¹ , Yuliang Ma¹ , Magda Claeys¹ , Luc Pieters¹ , Kabangu Kambu² , Lutete Tona² , Phongi Bakana² , Dirk Vanden Berghe¹ , Arnold J. Vlietinck¹

¹Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610 Antwerp, Belgium
²Faculty of Pharmacy, University of Kinshasa, B.P. 212, Kinshasa XI, Zaire

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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

A kaempferol 7-O-rhamnosylsophoroside isolated from the leaves of Morinda morindoides showed dose-dependent complement-modulating properties towards both the classical (inhibiting effect) and alternative (activating effect) pathways of the complement system. Its structure was elucidated by chemical and spectroscopic methods as kaempferol 7-O-[α-L-rhamnopyranosyl-(1→6)]-[β-D-glucopyranosyl-(1→2)]-β-D-glucopyranoside, a new natural product which was named morindaoside.

key words

Morinda morindoides - Rubiaceae - flavonol - kaempferol 7-O-rhamnosylsophoroside - complement-modulating properties