Hypoglycemic Effects of Sesquiterpene Glycosides and Polyhydroxylated Triterpenoids of Eriobotrya japonica

Nunziatina De Tommasi; Francesco De Simone; Giuseppe Cirino; Carla Cicala; Cosimo Pizza

doi:10.1055/s-2006-960137

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Planta Med 1991; 57(5): 414-416
DOI: 10.1055/s-2006-960137

Papers

Hypoglycemic Effects of Sesquiterpene Glycosides and Polyhydroxylated Triterpenoids of Eriobotrya japonica

Nunziatina De Tommasi¹ , Francesco De Simone¹ , Giuseppe Cirino² , Carla Cicala² , Cosimo Pizza¹

¹Dipartimento di Chimica delle Sostanze Naturali, Universita' di Napoli “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy
²Dipartimento di Farmacologia Sperimentale, Universita' di Napoli “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy

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Publikationsverlauf

1990

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

The effects of the constituent sesquiterpene glycosides 1 - 3 and polyhydroxylated triterpenoids 5 - 6 isolated by MeOH extraction of Eriobotrya japonica were studied in genetically diabetic mice (C57BL/KS-db/db/Ola) and normoglycemic rats. The sesquiterpene glycoside 3 and the polyhydroxylated triterpenoids 5 and 6 produced a marked inhibition of glycosuria. Furthermore, 5 and 6 were able to reduce blood glucose levels in normoglycemic rats. While there are already some data reported on hypoglycemic activity of polyhydroxylated triterpenoids, there are no previous data showing hypoglycemic activity of sesquiterpene glycosides.

Key words

Eriobotrya japonica - hypoglycemic effects - sesquiterpene glycosides - polyhydroxylated triterpenoids

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