A Novel Method for Preparing Isocyanides from N-Substituted Formamides with Chlorophosphate Compounds

Abstract

Treatment of N-substituted formamides with chlorophosphate compounds such as PhOPOCl₂, EtOPOCl₂, Me₂NPOCl₂, and (PhO)₂POCl and tertiary amines such as triethylamine, pyridine, and N,N-diisopropylethylamine produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides.

isocyanide - isonitrile - formamide - dehydration - dichlorophosphate - monochlorophosphate

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