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Planta Med 2012; 78(5): 485-487
DOI: 10.1055/s-0031-1298215
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Three New Diterpenoids from the Leaves of Thuja orientalis

Chung Sub Kim1 , Sang Un Choi2 , Kang Ro Lee1
  • 1Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea
  • 2Korea Research Institute of Chemical Technology, Daejeon, Korea
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Publikationsverlauf

received July 19, 2011 revised November 28, 2011

accepted January 9, 2012

Publikationsdatum:
31. Januar 2012 (online)

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Abstract

Three new diterpenoids, 18-formyloxy-8β-hydroxysandaracopimar-15-ene (1), 15(R)-n-butoxypinusolidic acid (2), and 15,16-dihydro-15,16-dimethoxylambertianic acid (3), along with twelve known compounds (4–15) were isolated from MeOH extracts of leaves of Thuja orientalis L. The structures of the three new compounds were elucidated on the basis of spectroscopic analyses, including extensive 2D-NMR data. The absolute stereochemistry of compound 2 was clarified by a CD spectroscopic study. The isolated compounds were evaluated for cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the sulforhodamin B (SRB) bioassay.

Key words

Thuja orientalis - Cupressaceae - diterpene - cytotoxicity

Supporting Information

References

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Prof. Dr. Kang Ro Lee

Natural Products Laboratory, School of Pharmacy
Sungkyunkwan University

300 Cheoncheon-dong

Jangan-gu

Suwon-si 440–746

Korea

Telefon: +82 3 12 90 77 10

Fax: +82 3 12 90 77 30

eMail: krlee@skku.ac.kr