Planta Medica, Inhaltsverzeichnis Planta Med 1998; 64(6): 516-519DOI: 10.1055/s-2006-957505 PapersPharmacology© Georg Thieme Verlag Stuttgart · New YorkPrenylflavonoids: A New Class of Non-Steroidal Phytoestrogen (Part 2). Estrogenic Effects of 18-Isopentenylnaringenin on Bone MetabolismMasaaki Miyamoto1 , Yoichi Matsushita1 , Akiko Kiyokawa1 , Chie Fukuda1 , Yasuteru lijima1 , Machiko Sugano2 , Toshiyuki Akiyama2 1Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Tokyo, Japan 2Exploratory Chemistry Research Laboratories, Sankyo Co., Tokyo, Japan Artikel empfehlen Abstract als PDF herunterladen(opens in new window) Artikel einzeln kaufen(opens in new window) Abstract In order to examine whether 8-isopentenylnaringenin (1), which has been proven to possess estrogen agonist activity in in vitro tests, also produces in vivo estrogenic properties, the effects of 1 on uterus and on bone metabolism were determined in ovariectomized rats. Rats were ovariectomized and treated with 1 at 30 mg/kg/day subcutaneously for two weeks or 17β-estradiol at 0.01 mg/kg/day subcutaneously for two weeks. Ovariectomy resulted in an increase in urinary excretion of bone resorption markers (hydroxyproline, pyridinoline and deoxypyridinoline) and a decrease in bone mineral density of the proximal tibia as well as reduced uterine weight. Treatment with 1 or 17β-estradiol completely suppressed these ovariectomy-induced bone and uterine changes in a qualitatively similar manner. These results demonstrate that 1 acts as an estrogen agonist in the uterus as well as in bone in vivo. Key words Prenylflavonoid - isopentenylflavanone - non-steroidal estrogen agonist - phytoestrogen - bone metabolism PDF (358 kb)
