Active Constituents Against HIV-1 Protease from Garcinia mangostana

Abstract

The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC₅₀ = 5.12 ± 0.41 µM) and γ-mangostin (IC₅₀ = 4.81 ± 0.32 µM). The type of inhibition by both compounds is noncompetitive.