Abstract
In order to establish the possible relationship between their chemical structures
and pharmacological properties, the oral and topical anti-inflammatory activities
of ten triterpenoids belonging to the lupane, oleanane, and ursane series, were evaluated.
All triterpenoids were remarkably active against the edema produced by TPA. While
the basic carbon skeleton has no influence on the activity, the presence of a C-28
or C-30 carboxylic group and an alcoholic group at C-28 increases the activity in
carrageenan- and EPP-induced edemas, respectively.
