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Planta Med 1995; 61(2): 182-185
DOI: 10.1055/s-2006-958045
Letters

© Georg Thieme Verlag Stuttgart · New York

Structural Requirements for the Anti-Inflammatory Activity of Natural Triterpenoids

María del Carmen Recio, Rosa María Giner, Salvador Máñez, José Luis Ríos
  • Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Avda. Vicent Andrés Estellés s/n, E-46100 Burjassot, València, Spain
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1994

1994

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

In order to establish the possible relationship between their chemical structures and pharmacological properties, the oral and topical anti-inflammatory activities of ten triterpenoids belonging to the lupane, oleanane, and ursane series, were evaluated. All triterpenoids were remarkably active against the edema produced by TPA. While the basic carbon skeleton has no influence on the activity, the presence of a C-28 or C-30 carboxylic group and an alcoholic group at C-28 increases the activity in carrageenan- and EPP-induced edemas, respectively.