Baicalin Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice

Chien-Hui Hung; Chien-Neng Wang; Huei-Hsuan Cheng; Jiunn-Wang Liao; Yi-Ting Chen; Ya-Wen Chao; Jia Liang Jiang; Chen-Chen Lee

doi:10.1055/a-0622-8242

Planta Medica, Table of Contents

Planta Med 2018; 84(15): 1110-1117
DOI: 10.1055/a-0622-8242

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Baicalin Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice

Chien-Hui Hung^*

¹Graduate Institute of Clinical Medical Science, College of Medicine, China Medicine University, Taichung, Taiwan

,

Chien-Neng Wang^*

²Institute of Basic Medical Science, College of Medicine, China Medicine University, Taichung, Taiwan

,

Huei-Hsuan Cheng

¹Graduate Institute of Clinical Medical Science, College of Medicine, China Medicine University, Taichung, Taiwan

,

Jiunn-Wang Liao

³Institute of Veterinary Pathology, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan

,

Yi-Ting Chen

⁴Department of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medicine University, Taichung, Taiwan

,

Ya-Wen Chao

⁴Department of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medicine University, Taichung, Taiwan

,

Jia Liang Jiang

⁵Graduate Institute of Biomedical Sciences, College of Medicine, China Medicine University, Taichung, Taiwan

,

Chen-Chen Lee

²Institute of Basic Medical Science, College of Medicine, China Medicine University, Taichung, Taiwan

⁵Graduate Institute of Biomedical Sciences, College of Medicine, China Medicine University, Taichung, Taiwan

⁶Department of Microbiology and Immunology, School of Medicine, China Medicine University, Taichung, Taiwan

› Author Affiliations

Abstract

Baicalin is the main flavonoid from the roots of an important medicinal plant, Scutellaria baicalensis, which shows a variety biological activities. Psoriasis is a chronic immune-mediated inflammatory disease that affects the skin. The unmet need of psoriasis is that many patients do not respond adequately to available clinical treatment. In this study, we found that baicalin showed inhibited dermal inflammation in a murine model of psoriasis via topical application of imiquimod. After a 5-day topical imiquimod application, baicalin or the control vehicle cream was to applied to the lesions of BALB/c mice for a further 4 days. The erythema, scaling, and thickness of the epidermal layer significantly improved in the baicalin-treated mice. The levels of interleukin-17A, interleukin-22, interleukin-23, and tumor necrosis factor in the skin significantly decreased after baicalin treatment. Baicalin also inhibited imiquimod-induced interleukin-17A production in skin draining lymph node cells. The infiltration of γδ T cells into the skin lesions induced by imiquimod was also suppressed after baicalin treatment. These results suggest that baicalin inhibited skin inflammation through the inhibition of the interleukin-17/interleukin-23 axis in a murine model of psoriasis.

Key words

baicalin - imiquimod - IL-17 - psoriasis - γδ T cells - Scutellaria baicalensis - Lamiaceae

Full Text

References

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