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Planta Med 2019; 85(03): 225-230
DOI: 10.1055/a-0740-3255
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Isoflavones from Camphorosma lessingii Inhibit the Organic Anion Transporters OAT1 and OAT3

Xinhui Wang
1   School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, China
,
Dujuan Wang
1   School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, China
,
Xue Wang
1   School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, China
,
Manana Khutsishvili
2   National Herbarium of Georgia, Ilia State University, Tbilisi, Georgia
,
Kamilla Tamanyan†
3   Institute of Botany, Armenian National Academy of Sciences, Yerevan, Armenia
,
George Fayvush
3   Institute of Botany, Armenian National Academy of Sciences, Yerevan, Armenia
,
Daniel Atha
4   New York Botanical Garden, Bronx, New York, USA
,
Youcai Zhang
1   School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, China
,
Robert P. Borris
1   School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, China
› Author Affiliations
Further Information

Publication History

received 06 April 2018
revised 03 September 2018

accepted 10 September 2018

Publication Date:
24 September 2018 (online)

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Abstract

Phytochemical investigation of Camphorosma lessingii has resulted in the isolation of four previously unreported isoflavones (1–4) and eight known compounds (5–12). Nine of these compounds (1–6, 8–10) are reported for the first time from members of the family Amaranthaceae. The structures of all isolated compounds were determined by spectroscopic methods, primarily one-dimensional and two-dimensional nuclear magnetic resonance and mass spectrometry. The absolute configuration of 6 was confirmed by circular dichroism. Inhibition of the organic anion transporters, OAT1 and OAT3, by the isolated compounds was evaluated. Among them, 7, 2′-dihydroxy- 6,8-dimethoxyisoflavone (1), 2′-hydroxy-6,7,8-trimethoxyisoflavone (2), 6,2′-dihydroxy-7,8-dimethoxyisoflavone (3), and 7-methoxyflavone (5) showed a significant inhibitory effect on 6-carboxyfluorescein uptake mediated by OAT1 and OAT3.

Key words

Amaranthaceae - Camphorosma lessingii - isoflavone - organic anion transporters - OAT1 - OAT3

Supporting Information

    1H NMR spectra and 13C NMR spectra of all of the compounds isolated in this study can be found in the Supporting Information.

  • Supporting Information
 

  • References

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