Antiprotozoal Germacranolide Sesquiterpene Lactones from Tanacetum sonbolii

Abstract

A phytochemical investigation of extracts from flowers and aerial parts of Tanacetum sonbolii afforded 7 new germacranolide sesquiterpene lactones. The structures were established by a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism. The in vitro antiprotozoal activity of the compounds against Trypanosoma brucei rhodesiense and cytotoxicity against rat myoblast (L6) cells were determined. Compounds 4 and 5 showed IC₅₀ values of 5.1 and 10.2 µM and selectivity indices of 3.9 and 4.0, respectively.

Key words

Tanacetum sonbolii - Asteraceae - sesquiterpene lactone - electronic circular dichroism - antiprotozoal activity - Trypanosoma brucei rhodesiense

• References

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