Subscribe to RSS
DOI: 10.1055/a-0921-7374
Geographic Clusters of Underimmunization Against Influenza in the Elderly: Westphalia-Lippe as an Example
Article in several languages: deutsch | English
Abstract
Background Underimmunization against influenza has been increasing in recent years. A spatial clustering of underimmunization is suspected. These clusters can pose risks to health care and make achieving immunization quality standards difficult. The objectives of this paper are to (a) identify and describe PLZ-level spatial clusters with high levels of underimmunization against influenza, (b) compare the clusters with other preventive services, and (c) model possible factors influencing underimmunization.
Material and methods From the routine data of the Association of Statutory Health Insurance physicians Westphalia-Lippe, patients ≥60 years and vaccinations between 2012–2017 were extracted. As a methodology, the spatial scan statistics were chosen, which show high relative risks of underimmunization in clusters.
Results and conclusion Four statistically significant clusters of underimmunization against influenza were identified, which proved to be stable even after adjustment with the temporal trend of local underimmunization rates. In the flu season 2016/2017, the underimmunization rate in the higher risk clusters (RR>1) was 71.9–74.7% and the rate outside these clusters was 67.0%. As influencing factors on underimmunization, socio-economic factors and vaccination behavior in the preseason were identified. Underimmunization rates are geographically clustered. The spatial scan statistics can be used for the identification of persistent clusters in order to carry out targeted spatial and addressee-specific measures to reduce underimmunization rates.
Publication History
Article published online:
23 August 2019
© 2019. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Robert Koch-Institut. Bericht zur Epidemiologie der Influenza in Deutschland,
Saison 2017/18, Berlin 2018
MissingFormLabel
- 2 Robert Koch Institut. Empfehlungen der Ständigen Impfkommission (STIKO) am RKI
2018/2019. Epidemiol Bull 2018; 34: 333-382
MissingFormLabel
- 3 World Health Organisation (WHO). WHO position paper on influenza vaccines. Wkly Epidemiol
Rec 2005; 80: 279-287
MissingFormLabel
- 4
Reuss AM,
Walter D,
Feig M.
et al. Influenzaimpfquoten der Saisons 2004/05, 2005/06 und
2006/07. Eine Sekundärdatenanalyse von Abrechnungsdaten der
Kassenärztlichen Vereinigungen. Dtsch Ärztebl Int 2010; 107: 845-850
MissingFormLabel
- 5 Bätzing-Feigenbaum J, Schulz et al. der saisonalen
Influenzastandardimpfraten im kassenärztlichen Versorgungssektor in
Deutschland seit der Pandemie 2009 – eine Trendanalyse auf regionaler
Ebene für den Zeitraum 2009/2010 bis 2013/2014.
Zentralinstitut für die kassenärztliche Versorgung in
Deutschland (Zi). Versorgungsatlas-Bericht Nr. 15/19. Berlin 2015
MissingFormLabel
- 6
Gravenstein S,
Davidson HE,
Taljaard M.
et al. Comparative effectiveness of high-dose versus standard-dose influenza
vaccination on numbers of US nursing home residents admitted to hospital: a
cluster-randomised trial. Lancet. Respir Med 2017; 5: 738-746
MissingFormLabel
- 7
Nichol KL,
Goodman M.
The health and economic benefits of influenza vaccination for healthy and
at-risk persons aged 65 to 74 years. PharmacoEconomics 1999; 16: 63-71
MissingFormLabel
- 8
Kitron U,
Kazmierczak JJ.
Spatial Analysis of the Distribution of Lyme Disease in Wisconsin. Am J Epidemiol
1997; 145: 558-566
MissingFormLabel
- 9
Kleinman K,
Lazarus R,
Platt R.
A Generalized Linear Mixed Models Approach for Detecting Incident Clusters of
Disease in Small Areas, with an Application to Biological Terrorism. Am J Epidemiol
2004; 159: 217-224
MissingFormLabel
- 10
Wen T-H,
Lin NH,
Chao D-Y.
et al. Spatial–temporal patterns of dengue in areas at risk of dengue
hemorrhagic fever in Kaohsiung, Taiwan, 2002. Int J Infect Dis 2010; 14: e334-e343
MissingFormLabel
- 11
Lieu TA,
Ray GT,
Klein NP.
et al. Geographic clusters in underimmunization and vaccine refusal. Pediatrics 2015;
135: 280-289
MissingFormLabel
- 12
Anselin L.
Local Indicators of Spatial Association – LISA. Geogr Anal 1995; 27: 93-115
MissingFormLabel
- 13
Fritz CE,
Schuurman N,
Robertson C.
et al. A scoping review of spatial cluster analysis techniques for point-event
data. Geospatial Health 2013; 7: 183-198
MissingFormLabel
- 14
Kulldorff M,
Nagarwalla N.
Spatial disease clusters: detection and inference. Stat Med 1995; 14: 799-810
MissingFormLabel
- 15
Kulldorff M.
A spatial scan statistic. Commun Stat – Theory Methods 1997; 26: 1481-1496
MissingFormLabel
- 16
Jorgensen P,
Mereckiene J,
Cotter S.
et al. How close are countries of the WHO European Region to achieving the goal of
vaccinating 75% of key risk groups against influenza? Results from
national surveys on seasonal influenza vaccination programmes, 2008/2009
to 2014/2015. Vaccine 2018; 36: 442-452
MissingFormLabel
- 17 Völker S Die Inanspruchnahme der ambulanten Notfallversorgung in
Westfalen-Lippe: eine medizingeographische Studie. Gesundheitswesen 2017; Im
Internet:
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-119082
MissingFormLabel
- 18
Omer SB,
Enger KS,
Moulton LH.
et al. Geographic Clustering of Nonmedical Exemptions to School Immunization
Requirements and Associations With Geographic Clustering of Pertussis. Am J Epidemiol
2008; 168: 1389-1396
MissingFormLabel
- 19
Pfeiffer DU,
Minh PQ,
Martin V.
et al. An analysis of the spatial and temporal patterns of highly pathogenic avian
influenza occurrence in Vietnam using national surveillance data. Vet J 2007; 174:
302-309
MissingFormLabel
- 20
Bödeker B,
Remschmidt C,
Schmich P.
et al. Why are older adults and individuals with underlying chronic diseases in Germany
not vaccinated against flu? A population-based study. BMC Public Health 2015; 15:
618
MissingFormLabel
- 21
Eastwood K,
Durrheim D,
Francis JL.
et al. Knowledge about pandemic influenza and compliance with containment measures
among Australians. Bull World Health Organ 2009; 87: 588-594
MissingFormLabel
- 22
Seale H,
Heywood AE,
McLaws M-L.
et al. need it? I am not at risk! Public perceptions towards the pandemic (H1N1) 2009
vaccine. BMC Infect Dis 2010; 10: 99
MissingFormLabel
- 23
Setbon M,
Raude J.
Factors in vaccination intention against the pandemic influenza
A/H1N1. Eur J Public Health 2010; 20: 490-494
MissingFormLabel
- 24
Feikin DR,
Lezotte DC,
Hamman RF.
et al. Individual and Community Risks of Measles and Pertussis Associated With Personal
Exemptions to Immunization. JAMA 2000; 284: 3145-3150
MissingFormLabel
- 25
Salmon DA,
Haber M,
Gangarosa EJ.
et al. Health consequences of religious and philosophical exemptions from immunization
laws: individual and societal risk of measles. JAMA 1999; 282: 47-53
MissingFormLabel
- 26
Andrew MK,
McNeil S,
Merry H.
et al. Rates of influenza vaccination in older adults and factors associated with
vaccine use: A secondary analysis of the Canadian Study of Health and Aging. BMC Public
Health 2004; 4: 36
MissingFormLabel
- 27
Bish A,
Yardley L,
Nicoll A.
et al. Factors associated with uptake of vaccination against pandemic influenza: a
systematic review. Vaccine 2011; 29: 6472-6484
MissingFormLabel
- 28
Rubin GJ,
Potts HWW,
Michie S.
The impact of communications about swine flu (influenza A H1N1v) on public
responses to the outbreak: results from 36 national telephone surveys in the
UK. Health Technol Assess Winch Engl 2010; 14: 183-266
MissingFormLabel
- 29
Vaux S,
Van Cauteren D,
Guthmann J-P.
et al. Influenza vaccination coverage against seasonal and pandemic influenza and
their
determinants in France: a cross-sectional survey. BMC Public Health 2011; 11: 30
MissingFormLabel
- 30
Fabry P,
Gagneur A,
Pasquier J-C.
Determinants of A (H1N1) vaccination: cross-sectional study in a population of
pregnant women in Quebec. Vaccine 2011; 29: 1824-1829
MissingFormLabel
- 31
Gaygısız Ü,
Gaygısız E,
Özkan T.
et al. Why were Turks unwilling to accept the A/H1N1 influenza-pandemic
vaccination? Peopleʼs beliefs and perceptions about the swine flu outbreak and
vaccine in the later stage of the epidemic. Vaccine 2010; 29: 329-333
MissingFormLabel
- 32
Ellis SE,
Coffey CS,
Mitchel EF.
et al. Influenza- and Respiratory Syncytial Virus–Associated Morbidity and
Mortality in the Nursing Home Population. J Am Geriatr Soc 51: 761-767
MissingFormLabel