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Planta Med 2020; 86(03): 190-197
DOI: 10.1055/a-1068-7983
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Topical Application of 7,3′,4′-Trihydroxyisoflavone Alleviates Atopic Dermatitis-Like Symptoms in NC/Nga Mice

Authors

  • Sang Hun Park‡

    1   Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea

  • Chang Hyung Lee‡

    1   Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea

  • Ji Yun Lee

    1   Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea

  • Hee Yang

    2   Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea
    3   Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea

  • Jong Hun Kim

    4   Department of Food Science and Biotechnology, Sungshin University, Seoul, Republic of Korea

  • Jung Han Yoon Park

    3   Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea
    5   Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea

  • Jong-Eun Kim

    6   Department of Food Science and Technology, Korea National University of Transportation, Jeungpyeong, Republic of Korea

  • Ki Won Lee

    1   Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
    2   Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea
    3   Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea
    5   Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea

Supported by: Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries 116030-3
Further Information

Publication History

received 26 June 2019
revised 18 November 2019

accepted 21 November 2019

Publication Date:
18 December 2019 (online)

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Abstract

Atopic dermatitis is a skin disease characterized by chronic inflammatory lesions, and new therapies are needed to address its rising prevalence. Soy isoflavone has been highlighted as a potential new cosmeceutical material that may have applications in atopic dermatitis care. We have developed a technique to attach an additional -OH group to the ortho position of -OH in the phenol ring using a special enzyme. By adding the -OH group to daidzein, 7,3′,4′-trihydroxyisoflavone can be generated for possible use as a cosmeceutical and functional food material. In this study, we sought to examine the anti-atopic effects of 7,3′,4′-trihydroxyisoflavone, an analog of daidzein. Topical application of 7,3′,4′-trihydroxyisoflavone reduced Dermatophagoides farina extract-induced atopic dermatitis symptoms in NC/Nga mice. Histological analysis demonstrated that 7,3′,4′-trihydroxyisoflavone suppressed D. farina extract-induced infiltration of eosinophils and mast cells into skin lesions. We also found that 7,3′,4′-trihydroxyisoflavone significantly reduces the D. farina extract-induced increases in serum IgE and macrophage-derived chemokine (CCL22) levels. We observed that 7,3′,4′-trihydroxyisoflavone suppresses atopic markers including macrophage-derived chemokine (CCL22) and thymus and activation-regulated chemokine (CCL17) in HaCaT cells. 7,3′,4′-Trihydroxyisoflavone also reduced TNF-α/IFN-γ-induced phosphorylation of ERK1/2 and JNK1/2. These results highlight several desirable properties of 7,3′,4′-trihydroxyisoflavone, which support its use as a cosmeceutical ingredient for the treatment of atopic dermatitis.

Key words

soybean - 7,3′,4′-trihydroxyisoflavone - atopic dermatitis - topical application