Planta Med 2021; 87(01/02): 124-135
DOI: 10.1055/a-1209-3252
Natural Product Chemistry and Analytical Studies
Original Papers

Diterpenoids from Leaves of Cultivated Plectranthus ornatus

Lidivânia Silva Freitas Mesquita
1   Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil
,
Taynara Simão Matos
1   Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil
,
Fábio do Nascimento Ávila
1   Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil
,
Alison da Silva Batista
1   Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil
,
Andréa Felinto Moura
2   Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Fortaleza-CE, Brazil
,
Manoel Odorico de Moraes
2   Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Fortaleza-CE, Brazil
,
Matheus Carlos Matos da Silva
3   Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza-CE, Brazil
,
Talles Luann Abrantes Ferreira
3   Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza-CE, Brazil
,
Nilberto Robson Falcão Nascimento
3   Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza-CE, Brazil
,
Norberto Kássio Vieira Monteiro
4   Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Fortaleza-CE, Brazil
,
Otília Deusdênia Loiola Pessoa
1   Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil
› Author Affiliations

Abstract

Two new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (313) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6 and 9 were moderately cytotoxic against HL-60, whereas 6 and 13 were more active on SF-295 and HCT-116.

Supporting Information



Publication History

Received: 10 January 2020

Accepted after revision: 23 June 2020

Article published online:
03 August 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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