Klin Monbl Augenheilkd 2020; 237(12): 1466-1467
DOI: 10.1055/a-1265-7105
Der interessante Fall

Interstitial Keratitis with Lipid Keratopathy Mimicking Corneal Opacity Induced by Brimonidine Tartrate Eye Drops

Interstitielle Keratitis mit Lipidkeratopathie ähnlich wie Hornhauttrübung mit Nebenwirkungen von Brimonidine-tartrate-Augentropfen
Yuka Kasuya
Ophthalmology, Jichi Medical University, Shimotsuke, Japan
,
Ichiya Sano
Ophthalmology, Jichi Medical University, Shimotsuke, Japan
,
Shinji Makino
Ophthalmology, Jichi Medical University, Shimotsuke, Japan
› Author Affiliations

Introduction

Lipid keratopathy can result from corneal sterile infiltration with neovascularization, and can be secondary to stromal corneal herpes, other corneal diseases, trauma, contact lens wear, or systemic diseases [1], [2], [3], [4], [5].

In 2017, Maruyama et al. [6] reported two cases of peripheral corneal opacity that developed after treatment with brimonidine tartrate (BT). BT ophthalmic solution, a topical α2-adrenoreceptor agonist, has been used for glaucoma therapy. To date, four reports including eight cases with corneal opacity induced by BT use have been described in Japan [6], [7], [8], [9].

Here, we present a case of a 77-year-old woman with unilateral lipid keratopathy mimicking corneal opacity induced by BT.



Publication History

Received: 21 March 2020

Accepted: 07 September 2020

Article published online:
07 December 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Alfonso E, Arrellanes L, Boruchoff SA. et al. Idiopathic bilateral lipid keratopathy. Br J Ophthalmol 1988; 72: 338-343
  • 2 Barchiesi BJ, Eckel RH, Ellis PP. The cornea and disorders of lipid metabolism. Surv Ophthalmol 1991; 36: 1-22
  • 3 Sharif Z, Sharif W. Corneal neovascularization: updates on pathophysiology, investigations & management. Rom J Ophthalmol 2019; 63: 15-22
  • 4 Chu HS, Hu FR, Yang CM. et al. Subconjunctival injection of bevacizumab in the treatment of corneal neovascularization associated with lipid deposition. Cornea 2011; 30: 60-66
  • 5 Pang Y, Zhang Q, Bao Y. A CARE-compliant article: ipsilateral progressive idiopathic lipid keratopathy: A case report. Medicine (Baltimore) 2019; 98: e16589
  • 6 Maruyama Y, Ikeda Y, Yokoi N. et al. Severe corneal disorders developed after brimonidine tartrate ophthalmic solution use. Cornea 2017; 36: 1567-1569
  • 7 Tsujinaka A, Takai Y, Inoue Y. et al. A case of bilateral deep stromal corneal opacity and vascularization after use of multiple antiglaucoma medications including brimonidine tartrate ophthalmic solution. Acta Ophthalmol 2019; 97: e948-e949
  • 8 Manabe Y, Sawada A, Mochizuki K. Corneal sterile infiltration induced by topical use of ocular hypotensive agent. Eur J Ophthalmol 2019; DOI: 10.1177/1120672119850080.
  • 9 Yorifuji A, Hosotani Y, Okamoto M. et al. Three cases of corneal disorders developed after brimonidine tartrate ophthalmic solution use. Ganka 2019; 61: 1527-1533