Chemical Constituents from Chloranthus elatior and Their Inhibitory Effect on Human Dihydroorotate Dehydrogenase

Abstract

A new sesquiterpene, chlorantholide G (1), a new sesquiterpene dimer, elatiolactone (2), and 2 new diterpenes, elatiorlabdane B (3) and elatiorlabdane C (4), together with 51 known compounds, were isolated from the aerial parts of Chloranthus elatior. The new structures including their absolute configurations were mainly established by mass spectrometric, NMR, and electronic circular dichroism experiments. All isolated compounds were tested for their anti-hDHODH activity. (4S,6R)-4-hydroxy-6-isopropyl-3-methylcyclohex-2-enone (5) and (4S,5R,9S,10R)-8(17),12,14-labdatrien-18-oic acid (29) were the most active compounds with IC₅₀ values of 18.7 and 30.7 µM, respectively.

Key words

Chloranthus elatior - Chloranthaceae - sesquiterpenes - sesquiterpene dimers - diterpenes - hDHODH inhibition

Publication History

Received: 19 November 2020

Accepted after revision: 31 March 2021

Article published online:
26 April 2021

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