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Synthesis 2021; 53(16): 2881-2888
DOI: 10.1055/a-1481-2023
DOI: 10.1055/a-1481-2023
paper
Dual Roles of TBHP-Enabled Regioselective Hydroetherification of (Trifluoromethyl)alkenes with Boronic Acids: Access to α-Trifluoromethyl β-Aryloxy Tertiary Alcohols
We thank the National Natural Science Foundation of China (21702064), the Guangdong Basic and Applied Basic Research Foundation (2020B1515020012), the Fundamental Research Funds for Central Universities (2019ZD19), the National Undergraduate Innovative and Entrepreneurial Training Program (202010561050) for financial support.
Abstract
The three-starting materials four-component reaction of (trifluoromethyl)alkenes, TBHP, and boronic acids is reported, delivering various useful α-trifluoromethyl-β-aryloxy tertiary alcohols in high yields and in an exclusively regioselective hydroetherification manner. TBHP serves as both the oxidant and nucleophile in this reaction, as well as the O-source of the products.
Key words
dual roles - fluorine - alcohol - 1,2-difunctionalization - boronic acid - (trifluoromethyl)alkene - multi-component reactionsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1481-2023.
- Supporting Information
Publication History
Received: 09 March 2021
Accepted after revision: 13 April 2021
Accepted Manuscript online:
13 April 2021
Article published online:
29 April 2021
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