Synthesis of β-Hydroxy Aryl Selenides via Transition-Metal-Free Three-Component Reaction of Arylamines, Elemental Selenium, and Epoxides

Abstract

An efficient protocol for the construction of valuable β-hydroxy aryl selenides from easily available arylamines, elemental selenium, and epoxides through a transition-metal-free radical process is described. A wide variety of β-hydroxy aryl selenides were obtained in good to excellent yields with excellent stereo- and regioselectivity. In this reaction, two C–Se bonds can be built along with the cleavage of a C–N and C–O bond, demonstrating the high step economy and efficiency of this approach.

Key words

arylamines - elemental selenium - β-hydroxy aryl selenides - epoxides - radical reactions

Publikationsverlauf

Eingereicht: 23. Februar 2021

Angenommen nach Revision: 05. Mai 2021

Accepted Manuscript online:
05. Mai 2021

Artikel online veröffentlicht:
31. Mai 2021

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