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DOI: 10.1055/a-1507-4153
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Chromium-Catalyzed Cross-Coupling Reactions by Selective Activation of Chemically Inert Aromatic C−O, C−N and C−H Bonds

Xuefeng Cong
1  College of Chemistry, Sichuan University, Chengdu, China (Ringgold ID: RIN12530)
,
2  College of Chemistry, Sichuan University, Chengdu, China (Ringgold ID: RIN12530)
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Transition-metal-catalyzed cross-coupling has appeared as one of powerful and useful tools in the formation of C–C and C–heteroatom bonds. Given that the resource of precious metals on earth is shortage, the use of earth-abundant metals as catalysts in developing cost-effective strategies of cross-coupling is one of trends to synthetic chemistry. Compared with the achievements using first-row metal catalysis of nickel, iron, cobalt, and even manganese, the group 6 metal chromium has rarely been used in promoting cross-coupling. This perspective will cover recent advances in Cr-catalyzed cross-coupling reactions by the transformations of chemically inert C(aryl)–O, C(aryl)–N and C(aryl)–H bonds, offering selective strategies for molecule construction. The ability of low-valent Cr with a high-spin state involving in the process of two-electron oxidative addition will be highlighted, which is different with the mechanism by single-electron-transfer that is traditionally proposed in chromium-mediated transformations. 1 Introduction 2 Cr-Catalyzed Kumada Coupling of Unactivated C(aryl)−O and C(aryl)−N Bonds 3 Cr-Catalyzed Reductive Cross-Coupling between Two Unactivated C(aryl)–Heteroatom Bonds 4 Cr-Catalyzed Functionalization of Unactivated C(aryl)–H Bonds 5 Conclusion and Outlook



Publication History

Received: 10 April 2021

Accepted after revision: 11 May 2021

Publication Date:
11 May 2021 (online)

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