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DOI: 10.1055/a-1578-8778
Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species[ # ]
Supported by: Velux Stiftung 1284Abstract
Efficient wound treatment that addresses associated infections and inflammation remains one of the big unmet needs, especially in low- and middle-income countries. One strategy for securing better healthcare can be using medicinal plants if sufficient evidence on their safety and therapeutic benefits can be ascertained. A unique novel opportunity could be photo-enhanced wound treatment with a combination of light-sensitive plant preparations and local exposure to daylight. Data mining strategies using existing resources offer an excellent basis for developing such an approach with many potential plant candidates. In the present analysis, we researched the 535 botanical drugs included in the Chinese pharmacopeia and identified 183 medicinal plant species, 82 for treating open wounds caused by trauma and 101 for inflammatory skin conditions. After further screening for reports on the presence of known photoactive compounds, we determined a core group of 10 scientifically lesser-known botanical species that may potentially be developed into more widely used topical preparations for photodynamic treatment of infected wounds. Our predictive approach may contribute to developing a more evidence-based use of herbal medicines.
Key words
herbal medicines - photodynamic therapy - wound treatment - Chinese pharmacopeia - traditional medicine# Dedicated to Prof. Dr. Otto Sticher on the occasion of his 85th birthday.
Supporting Information
- Supporting Information
A list of the botanical drugs from the CP that, based on some metabolites, could show potential photoactivity (Table 1S) is provided as supporting information.
Publication History
Received: 15 May 2021
Accepted after revision: 02 August 2021
Article published online:
15 September 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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References
- 1 Sticher O. Natural product isolation. Nat Prod Rep 2008; 25: 517-554
- 2 Wilson BAP, Thornburg CC, Henrich CJ, Grkovic T, OʼKeefe BR. Creating and screening natural product libraries. Nat Prod Rep 2020; 37: 893-918
- 3 Heinrich M. Ethnopharmacology and Drug Development. In: Mander L, Lui HW. eds. Comprehensive natural Products II Chemistry and Biology. Elsevier: Oxford; 2010: 351-381
- 4 Sticher O. Biochemical, pharmaceutical, and medical Perspective of Ginseng. In: Larry D L, Rudolf B, eds. Phytomedicines of Europe. ACS symposium series; 1998. 691. 221-240
- 5 National Pharmacopoeia Commission of China. Pharmacopoeia of Peopleʼs Republic of China, 2015 edition. China: China Medical Science Press; 2015: 1
- 6 Leon C, Lin Y. Chinese medicinal Plants herbal Drugs and Substitutes: An Identification Guide. Richmond, UK: Kew Press; 2017
- 7 Wang J, Wong YK, Liao F. What has traditional Chinese medicine delivered for modern medicine?. Expert Rev Mol Med 2018; 20: e4
- 8 Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ. Wound healing. J Chin Med Assoc 2018; 81: 94-101
- 9 Feng X, Zhou Y, Fang D. Study on the mechanism of traditional Chinese medicine intervention effect on wound healing. J Liaoning Tradit Chin Med 2015; 42: 1498-1501
- 10 Heinrich M, Jiang H, Scotti F, Booker A, Walt H, Weckerle C, Maake C. Medicinal plants from the Himalayan region for potential novel antimicrobial and anti-inflammatory skin treatments. J PharmPharmacol 2021; 73: 956-967
- 11 Oyama J, Fernandes Herculano Ramos-Milaré ÁC, Lopes Lera-Nonose DSS, Nesi-Reis V, Galhardo Demarchi I, Alessi Aristides SM, Juarez Vieira Teixeira J, Gomes Verzignassi Silveira T, Campana Lonardoni MV. Photodynamic therapy in wound healing in vivo: a systematic review. Photodiagnosis Photodyn Ther 2020; 30: 101682
- 12 Sun Y, Ogawa R, Xiao BH, Feng YX, Wu Y, Chen LH, Gao XH, Chen HD. Antimicrobial photodynamic therapy in skin wound healing: a systematic review of animal studies. Int Wound J 2020; 17: 285-299
- 13 Mansoori B, Mohammadi A, Amin Doustvandi M, Mohammadnejad F, Kamari F, Gjerstorff MF, Baradaran B, Hamblin MR. Photodynamic therapy for cancer: Role of natural products. Photodiagnosis Photodyn Ther 2019; 26: 395-404
- 14 Muniyandi K, George B, Parimelazhagan T, Abrahamse H. Role of photoactive phytocompounds in photodynamic therapy of cancer. Molecules 2020; 25: 4102
- 15 Stegelmeier BL, Davis TZ, Clayton MJ. Plant-induced photosensitivity and dermatitis in livestock. Vet Clin North Am Food Anim Pract 2020; 36: 725-733
- 16 Siewert B, Stuppner H. The photoactivity of natural products–an overlooked potential of phytomedicines?. Phytomedicine 2019; 60: 152985
- 17 Rkein AM, Ozog DM. Photodynamic therapy. Dermatol Clin 2014; 32: 415-425
- 18 Ghorbani J, Rahban D, Aghamiri S, Teymouri A, Bahador A. Photosensitizers in antibacterial photodynamic therapy: An overview. Laser Ther 2018; 27: 293-302
- 19 Cieplik F, Deng D, Crielaard W, Buchalla W, Hellwig E, Al-Ahmad A, Maisch T. Antimicrobial photodynamic therapy–what we know and what we donʼt. Crit Rev Microbiol 2018; 44: 571-589
- 20 Grinholc M, Nakonieczna J, Fila G, Taraszkiewicz A, Kawiak A, Szewczyk G, Sarna T, Lilge L, Bielawski KP. Antimicrobial photodynamic therapy with fulleropyrrolidine: Photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies. Appl Microbiol Biotechnol 2015; 99: 4031-4043
- 21 Schafer M, Schmitz C, Facius R, Horneck G, Milow B, Funken K, Ortner J. Systematic study of parameters influencing the actio of rose bengal with visible light on bacterial cells: Comparison between the biology effect and singlet-oxygen production. Photochem Photobiol 2000; 71: 514-523
- 22 Huang Z, Li L, Chen X, Xiao H, Zeng J. The therapeutic effects of Polygonum bistorta L. n-butyl alcohol on isolated heart ischemia of reperfusion injury. Sichuan Tradit Chin Med 2009; 27: 52-54
- 23 Liu X, Li W, Li X, Xia H, Chen F. Preliminary study on in vitro antimicrobial activity of extracts and monomer compounds of Polygonum bistorta L. Chin Tradit Herb Drugs 2006; (01) 51-53
- 24 Liu C, Wang X, Zeng J. Preliminary study on antimicrobial activity of Polygonum bistorta L. J Gannan Med Coll 2006; (04) 489-490
- 25 Wang G, Fei H, Zhao X, Zhao Y. The in vitro antibacterial activity of the total flavonoids from Polygonum bistorta L. J Taishan Med Coll 2019; 40: 410-412
- 26 Duwiejua M, Zeitlin IJ, Gray AI, Waterman PG. The anti-inflammatory compounds of Polygonum bistorta: isolation and characterisation. Planta Med 1999; 65: 371-374
- 27 Liu YH, Weng YP, Lin HY, Tang SW, Chen CJ, Liang CJ, Ku CY, Lin JY. Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells. Sci Rep 2017; 7: 1-15
- 28 Huang Y, Zeng J, Ye H, Huang S, Lai F. A study on the analgesic effect of Polygonum bistorta L. n-Butyl alcohol. J Gannan Med Coll 2004; 24: 12-13
- 29 Wang H, Huang B, Zhan Z, Huang L, Liu D, Du H. Latest research progress of chemical constituents and pharmacological activities of Polygonum bistorta L. Mod Tradit Chin Med Mater Medica-World Sci Technol 2020; 22: 2998-3007
- 30 Takashima J, Asano S, Ohsaki A. Mururins AC, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity. Planta Med 2002; 68: 621-625
- 31 Xianling Y. Optimization of the extraction process of anthraquinones by response surface methodology. Chin Arch Tradit Chin Med 2013; 31: 408-410
- 32 Shen BB, Yang YP, Yasamin S, Liang N, Su W, Chen SH, Wang XJ, Wang W. Analysis of the phytochemistry and bioactivity of the genus Polygonum of Polygonaceae. Digit Chin Med 2018; 1: 19-36
- 33 Vath P, Wamer WG, Falvey DE. Photochemistry and phototoxicity of Aloe emodin. Photochem Photobiol 2002; 75: 346-352
- 34 Qi Y. Therapeutic effect of Conyza herba resin aerosol on 188 cases of chronic tracheitis of wheezing type and pharmacological experiment study. J Mod Clin Med 1979; (01) 42-48
- 35 Ma J, Li J, Su Y, Zheng J. Effect of Conyza herba on pyloric ligation of gastric ulcer in rats and its mechanism. Chin Pharmacol Bull 2000; 17: 55
- 36 Sun R, Gao JL, Liu S. Research progress on Conyza blinii . Chin Tradit Herb Drugs 2018; 49: 4710-4714
- 37 Wang Y, Nie L, Fang L, Tang N, Lei Y, Jin W, Tang Z, Chen H. In vitro analysis on antibacterial activity of extract from Conyza blinii H. Lév. Genomics Appl Biol 2019; 38: 2200-2226
- 38 Yang CR, He ZT, Li XC, Zheng QT, He CH, Yang J, Morita T. Blinin, a neoclerodane diterpene from Conyza blinii . Phytochemistry 1989; 28: 3131-3134
- 39 Su Y, Chen L, Luo Y, Chai X, Lv M, Guo D. Chemical constituents and their antiulcerogenic studies on whole herb of Conyza blinii . Chin Tradit Herb Drugs 2007; 38: 332-334
- 40 Ma L, Liu J. The protective activity of Conyza blinii saponin against acute gastric ulcer induced by ethanol. J Ethnopharmacol 2014; 158: 358-363
- 41 Qi Y, Xu X, He H, Wang S, Yang C. Preliminary experimental research on the total saponin of Conyza herba. Chin Tradit Pat Med 1983; 36
- 42 Sichuan Chengdu Conyza Herba Treating Chronic Tracheitis Cooperative group. The drug and clinical study of Conyza herba in the treatment of chronic tracheitis. J New Med 1976; 7: 260-262
- 43 Marles RJ, Hudson JB, Graham EA, Soucy-Breau C, Morand P, Compadre RL, Compadre CM, Towers GHN, Arnason JT. Structure-activity studies of photoactivated antiviral and cytotoxic tricyclic thiophenes. Photochem Photobiol 1992; 56: 479-487
- 44 An S, Ge H, Liu Y, Li S, Zhang L. Anti-inflammatory analgesic and antibacterial effects of Echinopsis radix . J Henan Med Coll 2019; 31: 252-255
- 45 Sandjo LP, Kuete V, Siwe XN, Poumale HMP, Efferth T. Cytotoxicity of an unprecedented brominated oleanolide and a new furoceramide from the Cameroonian spice, Echinops giganteus . Nat Prod Res 2016; 30: 2529-2537
- 46 Wang Y, Li X, Zhang P. Research progress on chemical constituents and pharmacological activities of Echinopsis Radix . Chin Tradit Herb Drugs 2005; 36: 309-311
- 47 Hudson JB, Harris L, Teeple A, Towers GHN. The anti-HIV activity of the phytochemical α-terthienyl. Antiviral Res 1993; 21: 33-43
- 48 Wang Y, Li X, Meng D, Li N, Zhang Y. Chemical constituents of thiophenes from Echinops latifolius Tausch. J Shenyang Pharm Univ 2008; 25: 194-196
- 49 Mares D, Fasulo MP, Bruni A. Ultraviolet-mediated antimycotic activity of α-terthienyl on Microsporum cookei . J Med Veterinary Mycol 1990; 28: 469-477
- 50 Wu HB, Wu HB, Kuang MS, Lan HP, Wen YX, Liu TT. Novel bithiophene dimers from echinops latifolius as potential antifungal and nematicidal agents. J Agric Food Chem 2020; 68: 11939-11945
- 51 Hong J, Hu J, Zhang H, Liu K, Liu B. The influence on the content and antimicrobial antioxidant activity of polysaccharide extraction from radix Echinopsis by different extraction methods. Food Sci Technol 2017; 42: 232-235
- 52 Li X, Zhang W, Wang Y, An S, Zhu Y. Screening effective part of Echinopsis radix via bacteriostasis and anti-inflammatory activities. Chin J Exp Tradit Med Formulae 2015; 21: 138-141
- 53 Lin CC, Lin CH, Chiu HF, Hu MF. The pharmacological and pathological studies on Taiwan folk medicine (VII): The anti-inflammatory effect of Echinops grjiisii . Am J Chin Med 1992; 20: 127
- 54 Dai W, Liu Y, Liu Y, Zhai W, Qiao Y. Phototoxicity assessment of radix Echinopsis based on chemiluminescence method. Chin J Exp Tradit Med Formulae 2012; 18: 185-187
- 55 Zhao F, Wang S, Wu X, Yu Y, Yue Z, Liu B, Lin S, Zhu C, Yang Y, Shi J. Non-anthraquinones constituents from the roots of Knoxia valerianoides . China J Chin Mater Medica 2012; 37: 2092-2099
- 56 Hong Y, Ma L, Wang Y, Sun J, Hou G, Zhao F, Han J, Wang C. Anthraquinones and triterpenoids from roots of Knoxia roxburghii . China J Chin Mater Medica 2014; 39: 4230-4233
- 57 Hänsel R, Sticher O. Pharmakognosie – Phytopharmazie, 7th edition. Berlin: Springer-Berlin; 2010: 381
- 58 Comini LR, Núñez Montoya SC, Sarmiento M, Cabrera JL, Argüello GA. Characterizing some photophysical, photochemical and photobiological properties of photosensitizing anthraquinones. J Photochem Photobiol A Chem 2007; 188: 185-191
- 59 Xu H, Song Y. Bacteriostatic experiment of twelve species of Chin medicines and its compounds against Escherichia coli . Sichuan Anim Vet Sci 2004; 31: 24-25 28
- 60 Li X, Zhong L, Wang J. Study on acute toxicity and irritation of Euphorbia pekinensis and Knoxia valerianoides . China Pharm 2013; 24: 208-209
- 61 Yang Z, Wang Y, Wu C, Huang Y, Wang Q, Cheng X, Chen H. Toxicity experiment on Sargassum, radix Knoxiae, radix Ransul and flos Genkwa against radix Glycyrrhizae in the antagonism of 18 Chinese drugs. China J Chin Mater Medica 1989; 14: 48-50
- 62 Yang X. Study on toxicity of Knoxiae Radix and active components and quality standards of Gendarussa vulgaris [Dissertation]. Shanghai: Shanghai University of Traditional Chinese Medicine; 2013
- 63 Zhang J, Wang X, Cui Z, Hu Z, Ding S, Huang X. Advances on chemical constituents and pharmacological activities of Polygala japonica Houtt. Mod Chin Med 2015; 17: 1216-1222
- 64 Li TZ, Zhang WD, Yang GJ, Liu WY, Liu RH, Zhang C, Chen HS. New flavonol glycosides and new xanthone from Polygala japonica . J Asian Nat Prod Res 2006; 8: 401-409
- 65 Zhang D, Dan W. Chemical constituents from roots of Polygala japonica . Chin Tradit Herb Drugs 2005; 36: 1767-1771
- 66 Xue QC, Li CJ, Zuo L, Yang JZ, Zhang DM, Xue C. Three new xanthones from the roots of Polygala japonica Houtt. J Asian Nat Prod Res 2009; 11: 465-469
- 67 Quang TH, Cong PT, Yen DTH, Nhiem NX, Tai BH, Yen PH, Ngan NTT, Kim DC, Kim YC, Oh H, Minh CV, Kiem PV. Triterpenoid saponins and phenylpropanoid glycosides from the roots of Polygala japonica Houtt. with anti-inflammatory activity. Phytochem Lett 2018; 24: 60-66
- 68 Liu M, Zhu T, Guo S, Zhu H. Evaluation of the anti-inflammatory and analgesic activities of the total saponins extracted from fermented Polygala japonica HOUTT. Adv Mater Res 2013; 641 – 642: 931-934
- 69 Yuan M, Wan F. Observation of the antibacterial and analgesic effect of formula Polygala japonica Houtt. Chin Pharm J 1985; 20: 313
- 70 Li J, Nie Z, Zhu J. Experimental study on pharmacological action of formula Polygala japonica Houtt. oral liquid. Chin Tradit Pat Med 1997; 19: 35-36
- 71 Xu H. Polygala japonica Houtt. for topical treatment of snake bites. Chin Folk Ther 2011; 19: 20
- 72 Zhu T, Liu M, Guo S, Li X, Wang X. Study on the anti-inflammatory and analgesic effect of total saponin from fermented Polygala japonica Houtt. Chin J Hosp Pharm 2011; 31: 996-998
- 73 Morton RA, Earlam WT. Absorption spectra in relation to quinones: 1: 4-naphthaquinone, anthraquinone, and their derivatives. J Chem Soc 1941; 159-169
- 74 Huang G, Guo X, Li W, Xu L. Research progress on chemical compositions and pharmacological activities of Polygonum perfoliatum L. Guangzhou Chem Ind 2017; 45: 26-28
- 75 Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): Structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorganic Med Chem Lett 2001; 11: 1839-1842
- 76 Liu J, Zeng Y, Sun G, Yu S, Xu Y, He C, Li Z, Jin S, Qin X. Polygonum perfoliatum L., an excellent herbal medicine widely used in China: A review. Fr Pharmacol 2020; 11: 581266
- 77 Huang H, Zhang C, Yuan D, Zhou Z. Anti-inflammatory and antibacterial effects of Polygonum perfoliatum L.: an active site research. Anhui Med Pharm J 2008; 12: 595-596
- 78 Lei J, Yao N, Wang KW. Phytochemical and chemotaxomic study on Polygonum perfoliatum L. Biochem Syst Ecol 2013; 48: 186-188
- 79 Yang H. The therapeutic effect of Polygonum perfoliatum L. on herpes zoster. J New Chin Med 1978; 3: 18
- 80 Huang X, Jiang L, Wang S, Jiang X, Huang D. Antibacterial activity research of medical plants of Persicaria perfoliata . J Mod Med Heal 2013; 29: 3041-3044
- 81 Du J, Xiao H, Du G. Wound healing action and mechanism of Polygonum perfoliatum L. J Henan Univ Sci 2020; 39: 381-384
- 82 Liu Y, Fan W. Research progress of pharmacological effects and clinical application of Gangbangui. Asia-Pacific Tradit Med 2011; 7: 161-162
- 83 Long W, Li Y. Experimental study on the effect of relieving cough and reducing sputum of Polygonum perfoliatum L. Chin J Clin Ration Drug Use 2010; 3: 34-35
- 84 Fan D, Zhou X, Zhao C, Chen H, Zhao Y, Gong X. Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-β-D-glucuronide in Polygonum perfoliatum L. Fitoterapia 2011; 82: 805-810
- 85 Liu J. Result analysis of compound Gangbangui capsule used in acute toxicity experiment in mice. Electron J Clin Med Lit 2017; 4: 4967 4970
- 86 Yang H, Zhou L, Wu H, Hu J. A clinical study on the curative effect and mechanism of action of external applications of antipyretic detoxicate traditional Chinese drugs for treatment of traumatic infected wounds. J Tradit Chin Orthop Traumatol 2016; 28: 13-18 23
- 87 Sui J, Li F, Guo Y, Wei B, Jiang L. Research progress on chemical composition and pharmacological effects of Saururus chinensis and predictive analysis on quality marker. Sci Technol Food Ind 2020; 41: 353-360
- 88 Wang EC, Shih MH, Liu MC, Chen MT, Lee GH. Studies on constituents of Saururus chinensis . Heterocycles 1996; 43: 969-975
- 89 Chen H, Li X, Chen J. A study on the chemical constituents of the above ground parts of Saururus chinensis(2). Chin Pharm J 2019; 54: 360-363
- 90 Sun D, Duan F, Jiang J, Liao X, Xiang Z, Li S. Simultaneous determination of five flavonoid contents from the different drying process of Saururus chinensis (Lour.) Baill. by UPLC. J Guangdong Pharm Univ 2019; 35: 506-510
- 91 Xu C, Li X, Chen H, Wu Y. Research on the effect of contents from Saururus chinensis on H2O2-induced LO2 cell damage. J Nanjing Univ Tradit Chin Med 2012; 28: 163-164
- 92 Huang K, Pan L, Xiao D, Luo Y. Experimental study on central inhibition of chloroform extract from Saururus chinensis . Lishizhen Med Mater Medica Res 2015; 26: 1054-1055
- 93 Zeng W, Yu Y, Wang Y, Zhou L, Chen J. Research on the anti-inflammatory and analgesic effect of Saururus chinensis . China Med Her 2012; 9: 33-35
- 94 Xing D, Su S. Effects of total flavonoids of Saururus chinensis (Lour.) Baill on glucose and lipid metabolism in type II diabetic insulin resistance rats. Chin Tradit Pat Med 2013; 37: 1840-1842
- 95 Lv H, Zou L, Ma J, Wang S, Liu T, Ke X, Fu J. Anti-metastatic effects of extracts from Saururi Herba downregulating Runx2 activation on breast cancer. Chin J Exp Tradit Med Formula 2015; 21: 123-127
- 96 Tian L, Li X, Xu Y, Li E. Effect and mechanism of Saururus chinensis against herpes simplex virus. China J Chin Mater Medica 2012; 37: 1642-1645
- 97 Zhou J, Zhou L, Hou X, Liu Z. Study on in vitro antimicrobial activity of two extracts of Saururus chinensis . Jiangsu Agricutural Sci 2012; 40: 234-235
- 98 Wang Y, Zhou L. Pharmacological study on external lotion of Saururi Herba. J Pract Tradit Chin Intern Med 2000; 14: 11-12
- 99 Chen H, Li X, Chen J. Studies on the acute toxicity of Saururus chinensis extract from different medicament portions. China Med Her 2013; 10: 13-15
- 100 Feng S, He X, Kai O, Chen F, Huang Y. Optimization on total alkaloids extraction from Semiaquilegia adoxoides using response surface methodology and evaluation of its antioxidant activity in vitro . Tradit Chin Drug Res Clin Pharmacol 2018; 29: 199-204
- 101 Lin C, Zhang Y, Lu Y. Effect analysis of toxin dispersing beverage on purulent acne. J North Pharm 2019; 16: 84
- 102 Wang Z, Xiao R, Zhang L, Song Y. Bacterial inhibition test of toxin dispersing beverage on suppurative bacteria. Sichuan Anim Vet Sci 2003; 30: 20-21
- 103 Zhang H, Chen H, Shen W, Yan Q, Tan J, Xu C, Fan H, Miao J, Sun S. Research Progress on chemical constituents from Radix Semiaquilegiae. J Nanjing Med Univ 2018; 34: 205-209
- 104 Liu X, Ji Z. Studies on chemical constituents and antibacterial activity of Semiaquilegia adoxoides . Nat Prod Res Dev 2019; 31: 1177-1182
- 105 Han Y, Liu H, Li K, Dan T, Ge X. Research progress on antifungal activity of berberine and synthesis of its molecular probes. Chem World 2020; 61: 83-91
- 106 Wang G, Qi F, Gao Y, Xi Y, Zhang Z. Progress in preparation and application of berberrubine and derivatives. Yunnan Chem Technol 2020; 47: 1-8
- 107 Niu F. Studies on the constituents and quality control of Semiaquilegia adoxoides [Dissertation]. Shenyang: Shenyang Pharmaceutical University; 2006
- 108 Görner H, Miskolczy Z, Megyesi M, Biczók L. Photoreduction and ketone-sensitized reduction of alkaloids. Photochem Photobiol 2011; 87: 284-291
- 109 Gasparec Z, Lovric SK, Lovric M. The ultraviolet and visible absorption spectra of berberrubine. Can J Chem 1982; 60: 970-975
- 110 Zhang B. A case report of Tiankuizi poisoning. Shanxi J Tradit Chin Med 2002; 23: 843
- 111 Wang F, Liu J. Research progress on chemical constituents and pharmacological effects of Siphonostegia chinensis Benth. Heilongjiang Med Pharm 2008; 31: 61
- 112 Sun W, Pan Y, Guo X, Jin R, Fu S, Wu Z, Chen D, Jin L. Comparison study in blood-flow-promoting and blood-stasis-removing effects of Artemisia anomala S.Moore and Siphonostegia chinensis Renth. Acad J Shanghai Univ Tradit Chin Med 1997; 11: 68-72
- 113 Liu Y, Chen S. The comparison of pharmacological activity between Siphonostegia chinensis Benth. and Artemisia capillaris Thunb. Chin Tradit Herb Drugs 1994; 17: 38-40
- 114 Wang H, Chen X, Qiu H, Liu S. Research status of Trachelospermum jasminoides (Lindl.) Lem. Guid Chin Med 2012; 10: 93-94
- 115 Zhang J, Yin Z, Liang J, Diao Y. Chemical constituents from petroleum ether extract of Trachelospermum jasminoides . Chin Tradit Pat Med 2012; 34: 1939-1942
- 116 Tao J, Bo K, Wei Y, Wu C, Min J, Xing X, Xi X. Network pharmacology to identify the pharmacological mechanisms of a traditional Chinese Medicine derived from Trachelospermum jasminoides in patients with rheumatoid arthritis. Med Sci Monit 2020; 26: e922639 (1–14)
- 117 Tang X, Chen H, Zhou M, Zhang Y. Triterpenoids from canes with leaves of Trachelospermum jasminoides . Chin Tradit Herb Drugs 2006; 37: 171-174
- 118 Fatima T, Ijaz S, Crank G, Wasti S. Indole Alkaloids from Trachelospermum jasminoides . Planta Med 1987; 53: 57-59
- 119 Li M. Research progress on pharmacological effects of Trachelospermum jasminoides . Technol Econ Guid 2017; (25) 152-153
- 120 Li H, Zhu B, Xu Z. Research status of Caulis Trachelospermi . Cent South Pharm 2014; 12: 463-466
- 121 Li J, Zhang Q, Zhang T. Research progress on Trachelospermum jasminoides . J Hebei Tradit Chin Med Pharmacol 2016; 31: 55-58
- 122 Lai P, Fan C, Li A. The comparison of anti-inflammatory and analgesic effects of Trachelospermum jasminoides (Lindl.) Lem. and Ficus pumila L. Arch Tradit Chin Med 2003; 21: 154-155
- 123 Zhao CC. Study on the extraction and purification technology of total flavonoids of Trachelospermum jasminoides and its anti-inflammatory and analgesic pharmacological effects [Dissertation]. LiaoNing: Liaoning medicine School; 2011
- 124 Shi BB, Chen J, Bao MF, Zeng Y, Cai XH. Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity. Phytochemistry 2019; 166: 112060
- 125 Kim Y, Jung HJ, Kwon HJ. A natural small molecule voacangine inhibits angiogenesis both in vitro and in vivo . Biochem Biophys Res Commun 2012; 417: 330-334