Synthesis 2022; 54(06): 1652-1660
DOI: 10.1055/a-1690-4840
paper

Solvent- and Metal-Controlled Regiodivergent Synthesis of Tri­fluoromethylated Pyrazol-3-yl- and Pyrazol-5-ylphosphonates

,
Valentina A. Bychkova
,
Danila A. Kalugin
,
Irina P. Beletskaya
A. Yu. Mitrofanov is grateful to the Russian Science Foundation (RSF, grant no. 19-73-00168, development of the synthesis of 1). I. P. Beletskaya thanks the Russian Science Foundation (RSF, grant no. 19-13-00223, synthesis of pyrazoles 3 and 5).


Abstract

Convenient approaches to the selective syntheses of trifluoro­methylated pyrazol-3-yl- and pyrazol-5-ylphosphonates have been developed based on solvent- and metal-controlled reaction of diethyl (4,4,4-trifluoro-3-oxobut-1-yn-1-yl)phosphonate and monosubstituted hydrazines.

Supporting Information



Publication History

Received: 15 September 2021

Accepted after revision: 08 November 2021

Publication Date:
08 November 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
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