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Synthesis 2022; 54(12): 2907-2915
DOI: 10.1055/a-1743-0191
DOI: 10.1055/a-1743-0191
paper
Ru(II)-Catalyzed C–H Activation and Alkyne Annulation Reaction of Phenyl Indandiones: Synthesis of Spirobi[indene]diones
Authors
The authors thank the Science and Engineering Research Board (SERB) and the Council of Scientific and Industrial Research (CSIR) New Delhi for financial support via the GPP-0367 (CRG/2019/001898) and OLP 2038 projects. B. R. Bora thanks DST for the INSPIRE-SRF fellowship.
Abstract
A Ru(II)-catalyzed synthesis of spirobi[indene]dione from phenyl indandione and alkyne is reported. This metal-catalyzed cyclization reaction proceeds through hydroxy group directed C(sp2)–H bond activation, keto–enol tautomerization and alkyne annulation pathways.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1743-0191.
It contains copies of 1H NMR, 13C NMR, NOE and HRMS spectra of the synthesized compounds.
- Supporting Information (PDF)
Publication History
Received: 13 August 2021
Accepted after revision: 17 January 2022
Accepted Manuscript online:
17 January 2022
Article published online:
28 March 2022
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