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Synthesis 2022; 54(14): 3249-3261
DOI: 10.1055/a-1785-7191
DOI: 10.1055/a-1785-7191
paper
Design, Synthesis, and Screening of Pyridothieno[3,2-b]indole and Pyridothieno[3,2-c]cinnoline Derivatives as Potential Biologically Active Molecules
Authors
Ministry of Science and High Education of the Russian Federation (project FZEZ-2020-0004).
Abstract
New pyridothieno[3,2-b]indole and pyridothieno[3,2-c]cinnoline derivatives are designed and prepared from the corresponding 3-amino-2-arylthieno[2,3-b]pyridines. By a molecular docking method novel potential inhibitors of DNA gyrase B are identified among the thieno[2,3-b]pyridine derivatives. In addition, some of the prepared pyridothienoindoles exhibit in vivo antidote activity against the herbicide 2,4-D.
Key words
pyridothienoindoles - azide - thermolysis - antidote activity - DNA gyrase inhibitors - molecular docking - ADMETSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1785-7191.
- Supporting Information (PDF)
Publication History
Received: 31 December 2021
Accepted after revision: 02 March 2022
Accepted Manuscript online:
02 March 2022
Article published online:
19 May 2022
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