Rh(III)-Catalyzed Synthesis of 2-Nitro-2H-azirines via sp³ C–H Activation

Abstract

An expedient Rh(III)-catalytic method has been described to synthesis of 2-nitro-2H-azirine derivatives from easily accessible β-nitrooxime ethers via sp³ C–H activation process. This protocol features of low catalyst loading, very mild reaction conditions, and tolerating a diverse of functionalities in good yields. A possible reaction pathway is proposed involving [RhCp*Cl₂]₂-catalyzed sp³ C–H bond activation and pivalic acid elimination steps.

Key words

Rh(III) - 2-nitro-2H-azirine - derivatives - β-nitrooxime - sp³ C–H

Publikationsverlauf

Eingereicht: 14. Februar 2022

Angenommen nach Revision: 22. März 2022

Accepted Manuscript online:
22. März 2022

Artikel online veröffentlicht:
10. Mai 2022

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