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Eur J Pediatr Surg 2023; 33(01): 002-010
DOI: 10.1055/a-1896-5345
Original Article

Elective Delivery versus Expectant Management for Gastroschisis: A Systematic Review and Meta-Analysis

Authors

  • Yong Chen

    1   Department of Pediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore

  • Jiashen Zhao

    2   School of Medicine, National University of Singapore, Singapore, Singapore

  • Mashriq Alganabi

    3   Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada

  • Carmen Mesas-Burgos

    4   Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden

  • Simon Eaton 

    5   Department of Pediatric Surgery, University College, London Institute of Child Health, London, England

  • Tomas Wester

    6   Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden
    7   Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden

  • Agostino Pierro 

    3   Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada

Funding None.
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Abstract

Introduction The optimal timing of delivery for pregnancies complicated by prenatally diagnosed gastroschisis remains controversial. Therefore, the aim of this study was to find whether elective or expectant delivery is associated with improved neonatal outcome.

Materials and Methods MEDLINE and Embase databases were searched for studies up to 2021 that reported timing of delivery for prenatally diagnosed gastroschisis. A systematic review and meta-analysis were then performed in group 1: moderately preterm (gestational age [GA]: 34–35 weeks) elective delivery versus expectant management after GA 34–35 weeks; and group 2: near-term (GA: 36–37 weeks) elective delivery versus expectant management after GA 36–37 weeks. The following clinical outcomes were evaluated: length of stay (LOS), total parenteral nutrition (TPN) days, bowel morbidity (atresia, perforation, and volvulus), sepsis, time of first feeding, short gut syndrome and respirator days, and mortality.

Results Two randomized controlled trials (RCT)s and eight retrospective cohort studies were included, comprising 629 participants. Moderately preterm elective delivery failed to improve clinical outcomes. However, near-term elective delivery significantly reduced bowel morbidity (7.4 vs. 15.4%, relative risk = 0.37; 95% confidence interval [CI]: 0.18, 0.74; p = 0.005; I2 = 0%) and TPN days (mean difference =−13.44 days; 95% CI: −26.68, −0.20; p = 0.05; I2 = 45%) compared to expectant delivery. The mean LOS was 39.2 days after near-term delivery and 48.7 days in the expectant group (p = 0.06).

Conclusion Based on the data analyzed, near-term elective delivery (GA 36–37 weeks) appears to be the optimal timing for delivery of pregnancies complicated by gastroschisis as it is associated with less bowel morbidity and shorter TPN days. However, more RCTs are necessary to better validate these findings.

Keywords

gastroschisis - elective delivery - expectant management - meta-analysis

Note

Part of this work was presented in the Evidence and Guidelines report meeting (EUPSA 2021) and also selected for oral presentation at the 23rd EUPSA annual congress.


Supplementary Material



Publication History

Received: 02 June 2022

Accepted: 06 July 2022

Accepted Manuscript online:
11 July 2022

Article published online:
18 October 2022

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