CC BY-NC-ND 4.0 · SynOpen 2022; 06(04): 227-237
DOI: 10.1055/a-1942-6969
paper

Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B

Bharath Kumar Yasam
a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India
b   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India
,
a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India
b   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India
› Author Affiliations
Y.B. thanks the University Grants Commission, New Delhi, India for ­financial assistance in the form of a Fellowship.


IICT Communication no. IICT/Pubs./2022/207

Abstract

A flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton present in their structure is described featuring two different routes, with good overall yield. The key synthetic reactions utilized include Keck allylation, Evans asymmetric methylation, Grubbs metathesis, and Julia–Kocienski olefination.

Supporting Information



Publication History

Received: 10 August 2022

Accepted after revision: 07 September 2022

Accepted Manuscript online:
14 September 2022

Article published online:
12 October 2022

© 2022. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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