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Synthesis 2014; 46(01): 110-118
DOI: 10.1055/s-0033-1340083
DOI: 10.1055/s-0033-1340083
paper
Studies toward the Synthesis of Iejimalides A–D: Preparation of the C3–11 and C12–C24 Fragments
Further Information
Publication History
Received: 30 July 2013
Accepted after revision: 10 October 2013
Publication Date:
07 November 2013 (online)
Abstract
The convergent synthesis of the C3–C11 and C12–C24 fragments of the iejimalides A–D is described. The C3–C11 fragment is obtained by a cross-metathesis reaction, while the C12–C24 fragment is derived from a Still–Gennari modified Horner–Wadsworth–Emmons olefination.
Key words
iejimalides - macrolides - cross-metathesis - Horner–Wadsworth–Emmons - fragment synthesisSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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