Studies toward the Synthesis of Iejimalides A–D: Preparation of the C3–11 and C12–C24 Fragments

Abstract

The convergent synthesis of the C3–C11 and C12–C24 fragments of the iejimalides A–D is described. The C3–C11 fragment is obtained by a cross-metathesis reaction, while the C12–C24 fragment is derived from a Still–Gennari modified Horner–Wadsworth­–Emmons olefination.

Key words

iejimalides - macrolides - cross-metathesis - Horner–Wadsworth–Emmons - fragment synthesis

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