Planta Med 2023; 89(09): 890-902
DOI: 10.1055/a-2044-9129
Biological and Pharmacological Activity
Original Papers

Anti-arthritis Effects of Zingiberaceae Extracts on Models of Inflammatory Joint Disease

Patiwat Kongdang
1   Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Siriwan Ongchai
2   Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Natthakarn Chiranthanut
3   Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Dumnoensun Pruksakorn
1   Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
4   Musculoskeletal Science and Translational Research (MSTR) Center, Department of Orthopaedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
› Author Affiliations
This research was partially funded by Thailand Research Fund–Research and Researchers for Industries, grant number PHD58I0017.


Due to this becoming an aging society, the number of arthritis cases has been increasing. Unfortunately, some currently available medications can cause adverse effects. Using herbal remedies as a form of alternative medicine is becoming increasingly popular. Zingiber officinale (ZO), Curcuma longa (CL), and Kaempferia parviflora (KP) are herbal plants in the Zingiberaceae family that have potent anti-inflammatory effects. This study investigates the anti-inflammatory and chondroprotective effects of ZO, CL, and KP extracts on in vitro and ex vivo inflammatory models. The combinatorial anti-arthritis effect of each extract is also evaluated in an in vivo model. ZO extract preserves cartilaginous proteoglycans in proinflammatory cytokines-induced porcine cartilage explant in a fashion similar to that of CL and KP extracts and suppresses the expression of major inflammatory mediators in SW982 cells, particularly the COX2 gene. CL extract downregulates some inflammatory mediators and genes-associated cartilage degradation. Only KP extract shows a significant reduction in S-GAGs release in a cartilage explant model compared to the positive control, diacerein. In SW982 cells, it strongly suppresses many inflammatory mediators. The active constituents of each extract selectively downregulate inflammatory genes. The combined extracts show a reduction in inflammatory mediators to a similar degree as the combined active constituents. Reductions in paw swelling, synovial vascularity, inflammatory cell infiltration, and synovial hyperplasia are found in the combined extracts-treated arthritic rats. This study demonstrates that a combination of ZO, CL, and KP extracts has an anti-arthritis effect and could potentially be developed into an anti-arthritis cocktail for arthritis treatment.

Supporting Information

Publication History

Received: 10 October 2022

Accepted after revision: 13 February 2023

Article published online:
20 March 2023

© 2023. Thieme. All rights reserved.

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