Reductive Coupling of Sodium Sulfinates for the Synthesis of Thiosulfonates

Abstract

A reductive coupling reaction of sodium sulfinates for the synthesis of symmetrical/unsymmetrical thiosulfonates is developed. The reaction takes place in the presence of acetyl chloride and Hantzsch ester under mild conditions and exhibits broad functional group tolerance. Mechanistic studies suggest that a radical process is involved.

Key words

sulfoxides - sulfinyl radicals - thiosulfonates - radical reaction - reductive coupling

Publication History

Received: 24 February 2023

Accepted after revision: 29 March 2023

Accepted Manuscript online:
29 March 2023

Article published online:
25 April 2023

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