Cu(OTf)₂/TBHP/O₂-Mediated Tandem Oxidative Reaction: Easy Access to Benzopyrano[4,3-b]pyridines

Abstract

An effective tandem reaction of 4-aminocoumarins and 1,3-diarylpropenes mediated by Cu(OTf)₂/TBHP (tert-butyl hydroperoxide)/O₂ that provides various benzopyrano[4,3-b]pyridines in moderate to good yields is disclosed. The reaction proceeds through oxidative coupling, intramolecular cyclization, and dehydro-aromatization. This approach has the advantages of high atom-economy, environmental compatibility, and wide substrate scope.

Key words

tandem reaction - oxidative coupling - TBHP - 4-aminocoumarin - benzopyrano[4,3-b]pyridines

Publication History

Received: 07 February 2023

Accepted after revision: 31 March 2023

Accepted Manuscript online:
31 March 2023

Article published online:
08 May 2023

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