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Synthesis 2023; 55(17): 2702-2712
DOI: 10.1055/a-2096-7045
DOI: 10.1055/a-2096-7045
paper
A Nickel(II) Chloride and Tetrahydroxydiboron Cocatalyzed Facile Synthesis of Benzo[b]azepines with an Appended Fluorinated Side Chain
Authors
The authors are grateful for the financial support from the National Natural Science Foundation of China (No. 22271214).
Abstract
A novel nickel-catalyzed chemoselective cascade reaction strategy towards the synthesis of benzo[b]azepines was developed. The method is characterized by simple and mild conditions, low cost, and a wide range of substrates. This method enabled the facile and efficient synthesis of a series of 2,3,4,5-tetrahydro-1H-benzo[b]azepine analogues with an appended fluorinated side chain.
Key words
tetrahydroxydiboron - ethyl bromodifluoroacetate - nickel catalyst - radical cascade - benzo[b]azepinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2096-7045.
- Supporting Information (PDF) (opens in new window)
Publication History
Received: 19 April 2023
Accepted after revision: 22 May 2023
Accepted Manuscript online:
22 May 2023
Article published online:
19 June 2023
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