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DOI: 10.1055/a-2177-3959
Ocular Involvement in Congenital Infections – TORCH
Article in several languages: deutsch | English
Abstract
This review summarises the ophthalmological findings in congenital infections. Intrauterine infections are an important cause of childhood blindness. The most common infections are grouped under the acronym TORCH, which stands for Toxoplasma gondii, others, rubella, CMV, and herpes simplex. Overall, these infections are not very common in first-world countries during pregnancy, but are of particular importance because of the threat to vision. Diagnosis of infection or reactivation is a gynaecological challenge. However, ophthalmological examination of newborns can be appropriately targeted if the causative agent is known. The most important therapeutic agents used in the newborn are summarised.
Publication History
Received: 29 June 2023
Accepted: 14 September 2023
Article published online:
23 October 2023
© 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG
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Literatur
- 1 Mets MB, Chhabra MS. Eye manifestations of intrauterine infections and their impact on childhood blindness. Surv Ophthalmol 2008; 53: 95-111
- 2 McAuley J, Boyer KM, Patel D. et al. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Infect Dis 1994; 18: 38-72
- 3 Stray-Pedersen B, Jenum P. Current status of toxoplasmosis in pregnancy in Norway. Scand J Infect Dis Suppl 1992; 84: 80-83
- 4 Desmonts G, Couvreur J. [Congenital toxoplasmosis. Prospective study of the outcome of pregnancy in 542 women with toxoplasmosis acquired during pregnancy]. Ann Pediatr (Paris) 1984; 31: 805-809
- 5 Olariu TR, Press C, Talucod J. et al. Congenital toxoplasmosis in the United States: clinical and serologic findings in infants born to mothers treated during pregnancy. Parasite 2019; 26: 13
- 6 Olariu TR, Remington JS, McLeod R. et al. Severe congenital toxoplasmosis in the United States: clinical and serologic findings in untreated infants. Pediatr Infect Dis J 2011; 30: 1056-1061
- 7 Pleyer U, Gross U, Schlüter D. et al. Toxoplasmosis in Germany. Dtsch Arztebl 2019; 116: 435-444
- 8 Robert Koch-Institut. RKI-Ratgeber Toxoplasmose. Epid Bull 2018; (42) 451-457
- 9 Phan L, Kasza K, Jalbrzikowski J. et al. Longitudinal study of new eye lesions in children with toxoplasmosis who were not treated during the first year of life. Am J Ophthalmol 2008; 146: 375-384
- 10 Peyron F, LʼOllivier C, Mandelbrot L. et al. Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group. Pathogens 2019; 8: 24
- 11 Robert Koch-Institut. RKI-Ratgeber Röteln. Epid Bull 2018; (40) 429-437
- 12 Boppana SB, Britt WJ, Fowler K. et al. Pathogenesis of Non-Zika Congenital Viral Infections. J Infect Dis 2017; 216 (Suppl. 10) S912-S918
- 13 Gregg NM. Congenital cataract following German measles in the mother. Trans Ophthalmol Soc Austr 1942; 3: 35-46
- 14 Hussain AS, Ali SR, Mohammad N. et al. Aniridia: A Rare Manifestation Of Congenital Rubella Syndrome. J Ayub Med Coll Abbottabad 2019; 31: 131-133
- 15 Kaushik S, Choudhary S, Dhingra D. et al. Newborn Glaucoma: A Neglected Manifestation of Congenital Rubella Syndrome. Ophthalmol Glaucoma 2022; 5: 428-435
- 16 Tamayo ML, Garcia N, Bermudez Rey MC. et al. The importance of fundus eye testing in rubella-induced deafness. Int J Pediatr Otorhinolaryngol 2013; 77: 1536-1540
- 17 Freij BJ, South MA, Sever JL. Maternal rubella and the congenital rubella syndrome. Clin Perinatol 1988; 15: 247-257
- 18 Manicklal S, Emery VC, Lazzarotto T. et al. The “silent” global burden of congenital cytomegalovirus. Clin Microbiol Rev 2013; 26: 86-102
- 19 Robert Koch-Institut. Zytomegalievirus-Infektion. Epid Bull 2014; (03) 23-28
- 20 Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 2007; 17: 253-276
- 21 Kylat RI, Kelly EN, Ford-Jones EL. Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infection. Eur J Pediatr 2006; 165: 773-778
- 22 Gabrani C, Mitsikas D, Giannakou K. et al. Congenital Cytomegalovirus Infection and Ophthalmological Disorders: A Systematic Review. J Pediatr Ophthalmol Strabismus 2023; 60: 86-94
- 23 Anderson KS, Amos CS, Boppana S. et al. Ocular abnormalities in congenital cytomegalovirus infection. J Am Optom Assoc 1996; 67: 273-278
- 24 Coats DK, Demmler GJ, Paysse EA. et al. Ophthalmologic findings in children with congenital cytomegalovirus infection. J AAPOS 2000; 4: 110-116
- 25 Demmler-Harrison GJ. Congenital cytomegalovirus infection: Management and outcome. Im Internet (Stand: 27.6.2023): https://www.uptodate.com/contents/congenital-cytomegalovirus-infection-management-and-outcome
- 26 Brown ZA, Selke S, Zeh J. et al. The acquisition of herpes simplex virus during pregnancy. N Engl J Med 1997; 337: 509-515
- 27 Leung KKY, Hon KL, Yeung A. et al. Congenital infections in Hong Kong: an overview of TORCH. Hong Kong Med J 2020; 26: 127-138
- 28 Kimberlin DW, Lin CY, Jacobs RF. et al. Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics 2001; 108: 230-238
- 29 Rasmussen SA, Jamieson DJ, Honein MA. et al. Zika Virus and Birth Defects–Reviewing the Evidence for Causality. N Engl J Med 2016; 374: 1981-1987
- 30 Ventura CV, Maia M, Ventura BV. et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol 2016; 79: 1-3
- 31 Ventura CV, Maia M, Dias N. et al. Zika: neurological and ocular findings in infant without microcephaly. Lancet 2016; 387: 2502
- 32 Jenson HB. Congenital syphilis. Semin Pediatr Infect Dis 1999; 10: 183-194
- 33 Herremans T, Kortbeek L, Notermans DW. A review of diagnostic tests for congenital syphilis in newborns. Eur J Clin Microbiol Infect Dis 2010; 29: 495-501
- 34 Robert Koch-Institut. RKI-Ratgeber Syphilis. Aktualisierung November 2020. Im Internet (Stand: 28.09.2023): https://www.rki.de/DE/Content/Infekt/EpidBull/Merkblaetter/Ratgeber_Syphilis.html%23doc2382636bodyText1
- 35 American Academy of Pediatrics. Syphilis. In: Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH. eds. Red Book: 2021 – 2024 Report of the Committee on Infectious Diseases. 32. ed.. Itasca, IL: American Academy of Pediatrics; 2021: 729