Nitro Compounds/Alcohols as Oxidant/Reductant Pairs: A Practical Synthesis of Azo Compounds and Ketones

Renchao Ma; Ruiqin Zhang; Huanyi Qiu; Jianhui Xie; Yongmin Ma

doi:10.1055/a-2226-4152

Synthesis, Table of Contents

Synthesis 2024; 56(05): 851-859
DOI: 10.1055/a-2226-4152

paper

Nitro Compounds/Alcohols as Oxidant/Reductant Pairs: A Practical Synthesis of Azo Compounds and Ketones

Authors

Renchao Ma‡

^aInstitute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. of China
Ruiqin Zhang‡

^bSchool of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. of China
Huanyi Qiu

^bSchool of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. of China
Jianhui Xie

^aInstitute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. of China
Yongmin Ma∗

^aInstitute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. of China

Abstract

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Abstract

Herein, a practical and green method for the synthesis of azobenzenes and ketones is reported using nitro compounds/alcohols as oxidant/reductant pairs under basic conditions. Alcohols and nitro compounds are oxidized/reduced in the absence of any metal catalysts under mild conditions and good yields of the corresponding ketones and azobenzenes are achieved selectively. In addition, the alcohols can even be oxidized with KNO₃ or NaNO₂.

Key words

nitroarenes - azobenzenes - alcohols - ketones - oxidation - reduction

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References

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Supplementary Material

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