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DOI: 10.1055/a-2260-5051
Trauma and Posttraumatic Stress Disorder as Important Risk Factors for Gestational Metabolic Dysfunction
Funding Supported by the National Institute of Health: MH115174 (V.M.).![](https://www.thieme-connect.de/media/ajp/EFirst/lookinside/thumbnails/10-1055-a-2260-5051_23aug0548-1.jpg)
Abstract
Gestational metabolic diseases adversely impact the health of pregnant persons and their offspring. Pregnant persons of color are impacted disproportionately by gestational metabolic disease, highlighting the need to identify additional risk factors contributing to racial-ethnic pregnancy-related health disparities. Trauma exposure and posttraumatic stress disorder (PTSD) are associated with increased risk for cardiometabolic disorders in nonpregnant persons, making them important factors to consider when identifying contributors to gestational metabolic morbidity and mortality health disparities. Here, we review current literature investigating trauma exposure and posttraumatic stress disorder as psychosocial risk factors for gestational metabolic disorders, inclusive of gestational diabetes, low birth weight and fetal growth restriction, gestational hypertension, and preeclampsia. We also discuss the physiological mechanisms by which trauma and PTSD may contribute to gestational metabolic disorders. Ultimately, understanding the biological underpinnings of how trauma and PTSD, which disproportionately impact people of color, influence risk for gestational metabolic dysfunction is critical to developing therapeutic interventions that reduce complications arising from gestational metabolic disease.
Key Points
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Gestational metabolic diseases disproportionately impact the health of pregnant persons of color.
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Trauma and PTSD are associated with increased risk for cardiometabolic disorders in nonpregnant per.
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Trauma and PTSD impact physiological cardiometabolic mechanisms implicated in gestational metabolic.
Keywords
trauma - PTSD - stress - metabolic disorders during pregnancy - gestational diabetes mellitus - hypertensive disorders of pregnancy - fetal growth restrictionPublication History
Received: 31 August 2023
Accepted: 28 January 2024
Accepted Manuscript online:
02 February 2024
Article published online:
06 March 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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