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Planta Med 2025; 91(03): 109-118
DOI: 10.1055/a-2486-8873
Original Papers

Phytochemical Characterization and Comparative Analysis of Cycloartane-Type Triterpenes in Astragalus adsurgens and Astragalus membranaceus

Guanglian Zhou‡
1   State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
3   Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
,
Yin Chen‡
3   Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
,
Bingyan Xu
3   Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
,
Guoqing Peng
1   State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
3   Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
,
Li Wang
2   Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
3   Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
,
Jian-Ping Huang 
2   Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
3   Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
,
Zhiyin Yu
1   State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2   Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
,
Sheng-Xiong Huang
1   State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
3   Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
› InstitutsangabenThis research was funded by the National Natural Science Foundation of China (82 225 043, 22 107 014, and 32 271 480) and the “Xinglin Scholar” Research Promotion Project of Chengdu University of TCM (BSH2021034).
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Abstract

Astragalus adsurgens, a significant forage plant cultivated in arid regions of northwest China, remains underexplored for its triterpenoid saponins and medicinal properties compared to the extensively studied Astragalus membranaceus. To explore the phytochemical profile of A. adsurgens for its potential application in the medical field, we employed ultra-pressure liquid chromatography coupled with a tandem mass spectrometry-based method to identify cycloartane-type triterpenes. Eventually, five new cycloartane-type triterpenoids, adsurgosides A – D (

1 – 4) and 3-methyl-3,4-seco-cyclostellanol (5), together with two known analogs, cycloastragenol (6) and cyclopycanthogenin (7), were isolated from the roots of A. adsurgens. Their structures were elucidated using 1D and 2D NMR analyses in combination with HRESIMS data. Additionally, a comparative study on the distribution patterns of these compounds revealed qualitative and quantitative variations between A. adsurgens and A. membranaceus. Our findings not only identified an alternative plant for isolating cycloartane-type triterpenoids but also offer new insights into the chemical properties of A. adsurgens.

Keywords

Fabaceae - Astragalus adsurgensb - Astragalus membranaceus - chemical constituents - cycloartane-type triterpenoids - target metabolites analysis

Supporting Information

    UPLC-Q-TOF-MS data of A. adsurgens and A. membranaceus and MS/MS spectra of compounds 2 – 7 in A. adsurgens as well as NMR spectra of compounds 1 – 5 are available as Supporting Information.

  • Ergänzendes Material


Publikationsverlauf

Eingereicht: 30. April 2024

Angenommen nach Revision: 25. November 2024

Accepted Manuscript online:
25. November 2024

Artikel online veröffentlicht:
08. Januar 2025

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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