Tetrel Bonding between an sp2 Nitrogen Atom and an sp3 C–N σ* Bond Stabilizes a cis-Amide Geometry

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Synfacts 2025; 21(05): 530
DOI: 10.1055/a-2557-9945

Innovative Drug Discovery and Development

Tetrel Bonding between an sp² Nitrogen Atom and an sp³ C–N σ* Bond Stabilizes a cis-Amide Geometry

Contributor(s):

Antonia F. Stepan (Roche)

,

Nicholas A. Meanwell (Baruch S. Blumberg Inst., U. Michigan, Rutgers. U.)

conformational bias - tetrel bonding - n→σ* interaction

Article published online:
22 April 2025

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