DOI: 10.1055/s-00000131

Synfacts

Issue 05 · Volume 21 · May 2025 DOI: 10.1055/s-015-61575

Synthesis of Natural Products

z443
All PDFs of this category
443
Total Synthesis of (–)-Rubriflordilactone B
444
Total Synthesis of (+)-Kobusine
445
Total Synthesis of (–)-Janthinoid A
446
Total Synthesis of (+)-Berkeleyacetal D
447
Total Synthesis of (–)-ent-Caucanolide E and (+)-Caucanolide F
448
Total Synthesis of (–)-Asperone A
449
Total Synthesis of (+)-Shahamin K

Synthesis of Heterocycles

z451
All PDFs of this category
451
Selective and Sequential Aryne Generations to Build Multisubstituted Naphthalenes
452
Rational Catalyst Design for the Asymmetric Ring-Opening of Azetidines
453
Transition-Metal-Free Selective C2- or C4-Alkylation of Pyridines
454
Modular Bioisosteric Replacement of Pyridine Cores with Benzonitriles
455
Three-Step Sequence for the Formal β-C(sp3)–H Fluorination of N-Substituted Amines
456
A One-Pot Three-Component Synthesis of 2,4-Substituted Quinazolines
457
Aerobic Oxidative Cyclization of N-Containing Heterocycles by Perylene Diimide Catalysis
458
Construction of 5-Substituted Oxazoles from Aryl Methyl Ketones Using PIDA
459
Employing Manganese in Cascade Cyclization of Tertiary Enamides into 1,2-Dihydropyridines and Pyridines

Synthesis of Materials and Unnatural Products

z461
All PDFs of this category
461
Ligand-Stabilized Triplet Nitrenes
462
Silyllithium-Promoted Ring Expansion of Bicyclobutanes
463
From Boroles to Borirenes
464
π-Extended Indoloindolizine: A New Semiconducting Module
465
A [2,2]Pyrenophane from Photodesulfurization
466
Azuacenes: Azulene-Fused Acenes
467
Imine-to-Olefin Switching in Single-Crystal Covalent Organic Frameworks
468
Creating Spirocenters in Polymerization
469
Dithioacetal Polymers from Photopolycondensation
470
Ring Expansion Metathesis Polymerization of Polar Monomers
471
Decarboxylative Ring-Opening Polymerization of N-Carboxyanhydrides

Metals in Synthesis

z473
All PDFs of this category
473
Synthesis of Bicyclic Piperidines Enabled by a Palladium(IV) Dyotropic Rearrangement
474
Visible-Light-Driven Gold-Catalyzed Cross-Coupling of Aryl Bromides with Carboxylic Acids
475
Regiodivergent Synthesis of Cyclohexenes and Cyclobutenes under Palladium Catalysis
476
Iron-Catalyzed Alkenylzincation of Terminal Allenes with Abnormal Regioselectivity
477
Enantioselective Aziridination of Methyleneoxindoles Enabled by Nickel Catalysis
478
Catalytic Deoxygenative Arylation of Amides with Aryl Iodides to Access β-Aryl Amines
479
One-Pot Diazotization and Asymmetric Heck Reaction between Anilines and Unactivated Alkenes
480
Iridium-Catalyzed Enantioselective Partial Hydrogenation of Quinolines to 1,4-Dihydroquinolines
481
Synthesis of Five- and Six-Membered Rings from Dienes Catalyzed by Nickel
482
Asymmetric C(sp3)–H Functionalization of Allylic Ethers under Dual Nickel and Photoredox Catalysis
483
A Rhodium- and NHC-Catalyzed One-Pot Sequence for the Synthesis of Pyrrole-Fused Lactones
484
Synthesis of Isocyanates by Light-Driven Nickel-Catalyzed Carbonylative Azidation of Alkyl Iodides
485
Directed Silylalkenylation of ortho-C–H Bonds Catalyzed by Rhenium
486
Palladium-Catalyzed Skeletal Rearrangement of Small-Ring Carboxylic Acids to α,β-Unsaturated δ/γ-Lactones
487
[8+1] Cycloaddition of Vinyl Biscyclopropanes with CO Catalyzed by Rhodium
488
Copper-Catalyzed Asymmetric Epoxidation of Aldehydes with α-Trifluoromethyl Diazosilanes
489
Photochemical Palladium-Catalyzed Functionalization of 4-Acetoxy Piperidines via 1,5-Hydrogen Atom Transfer
490
Nickel-Catalyzed Regiodivergent Hydrocyanation of Alkynes
491
Asymmetric Synthesis of Spirocycles via Nickel-Catalyzed Alkenylation of Bisnucleophiles
492
Copper-Catalyzed anti-Selective Silylarylation of Benzylacetylenes
493
Trifluoromethyl Thiosulfonylation of Aryl Silicon Nucleophiles under Bismuth Catalysis
494
Regio- and Stereoselective Desymmetrization of Alkyne-Tethered Cyclic 1,3-Diones to Access Hydrobenzofurans
495
Combination of Rh-Hydrogen-Borrowing Catalysis and Pd-Catalyzed α-Arylation to Access α-Aryl Amines
496
Palladium-Catalyzed Asymmetric Heck/Tsuji–Trost Allylic Alkoxylation of Cyclohexadiene Derivatives
497
Synthesis of Chiral Allylic Sulfones via Regio- and Enantioselective Protoboration of Allenyl Sulfones
498
Accessing Cyclopentenones via Intramolecular Rhodium-Catalyzed Hydroacylation of Alkynyl Aldehydes

Polymer-Supported Synthesis

z499
All PDFs of this category
499
Photocatalytic Aerobic Oxidation of Amines Using Poly(phenylene ethynylene)
500
Nickel-Catalyzed Aryl-Carbonylative Ring-Opening of Oxiranes/Oxetanes under Electroreductive Conditions
501
Direct Dehydrative Esterification Using a Chitosan-Supported Ionic Liquid Catalyst
502
Aerobic Oxidation of Alcohols and Sulfides Using a Terbium MOF Catalyst under Photoirradiation
503
Diazenylation of Cyclic 1,3-Dicarbonyl Compounds with Aryldiazonium Tetrafluoroborates Using a TiO2 Catalyst
504
β-Selective Functionalization of Styrenes Using a Triazine-Based COF Photocatalyst
505
Difluoromethylation/Cyclization of 2-Isocyanobiaryls with an N-Phenylphenothiazine-Based Polymer Catalyst
506
Selective Hydrogenation of Nitroarenes with a Graphene-Supported Co/Mn Bimetallic Catalyst
507
Borylation of C(sp3)–O Bonds of Alkyl Ethers by Using Gold Nanoparticles Supported on α-Fe2O3
508
Hydrogenative Hydrogenolysis of Aromatic Aldehydes Using Single-Atom Palladium Supported on COF
509
Formation of Quinoline N-Oxides by Electrochemical Reductive Cyclization of 2-AllylNitroarenes

Organo- and Biocatalysis

z511
All PDFs of this category
511
Synergistic Phase-Transfer Catalysis for Nucleophilic Fluorination
512
An Acridinium Photocatalyst Enables Anti-Markovnikov Hydration of Unconjugated Olefins
513
Biomimetic Photodecarboxylation of Amino Acids
514
Asymmetric Radical Azidation via Bioinspired Copper/Amine Cooperative Catalysis
515
para-Selective C–H Alkylation via Radical tele-Substitution
516
Organo-Electro Catalysis for Asymmetric Biaryldiol Synthesis
517
Haloperoxidases: Vanadium-Dependent Metalloenzymes for Sustainable Halogenation
518
Controlled Partial and Complete Reductions of Furans Catalyzed by Simple Brønsted Acids
519
Electrophilic Bromination of Electron-Deficient Arenes
520
Asymmetric Imine Addition to Azabicyclo[1.1.0]butanes as Precursors to 2-Substituted Bicyclo[1.1.1]pentanes

Innovative Drug Discovery and Development

z521
All PDFs of this category
521
Organocatalyst for Regioselective Lactonization
522
Regioselective Thiolation of 2,4-Dihalopyrimidines
523
New Synthesis of Mirogabalin – A Counterintuitive Approach
524
A Quick Ibogaine Synthesis Amenable to Late-Stage Diversification
525
Stereodivergent Sequential Catalysis Provides Access to Highly Functionalized Oxindoles
526
Are You Positive? Establishing Cocaine Protonation upon DAT Binding with pH-Sensitive Anthracene Probe
527
‘Cut-and-Sew’ Aryne Insertion into Benzocyclobutenones
528
Skeletal Editing Approach to Synthesize Fluorinated Oxetane Isosteres
529
Ruthenium-Catalyzed N-Heterocycle Allylation via C–H Activation
530
Tetrel Bonding between an sp2 Nitrogen Atom and an sp3 C–N σ* Bond Stabilizes a cis-Amide Geometry
531
The Development of a Ratiometric Low-Affinity Calcium Indicator
532
Proteomic Profiling of Rabeprazole’s Cellular Targets and Its Zinc-Mediated Activity
533
mRNA Display Elicits Cyclic Peptide Covalent Binders of Staphylococcus aureus Serine Hydrolase

Peptide Chemistry

z535
All PDFs of this category
535
Peptide Stapling and Conjugation via Reversible Crosslinking of Two Alkyl Amines Using Formamidine
536
Cobalt-Catalyzed Reductive Tandem Reaction for the General Synthesis of Functional Amino Acids
537
Synthesis of Biaryl α-Amino Acids from Tyrosine via One-Pot Palladium-Catalyzed Arylation
538
Synthesis of Chiral β-Amino Esters from Diazoesters and N‐Methyl Tertiary Amines Using an Iridium Complex
539
Synthesis of Quinoxalinones Containing Heteroaryl Alanines and Oligopeptides
540
Synthesis of Cyclohexyl Analogues of Clovibactin
541
Chemical Synthesis of Stylissamide H
542
Pd(II)-Catalyzed C(sp2)–H Arylation of Dehydroalanine-Containing Peptides with Arylthianthrenium Salts
543
Flavin-Catalyzed Deprotection of C-Terminus Arylacyl Esters
544
Redox-Neutral Photocatalytic Phosphorylation of Tyrosine and Tyrosine-Containing Peptides
545
C–S Bond Activation of N-Aryl-α-benzylthio Glycine Esters to Access N-Aryl-α-arylated Glycine Esters
546
Asymmetric Strecker Synthesis for the Synthesis of α-Amino Nitriles

Flow Chemistry

z547
All PDFs of this category
547
Continuous-Flow Synthesis of Cyclopropanes Enabled by Electroreductive Nickel Catalysis