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Planta Med 2025; 91(05): 271-273
DOI: 10.1055/a-2560-1844
Reviews

Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps

Amin Sharifan 
Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems, Krems an der Donau, Austria
› InstitutsangabenThis research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
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Abstract

The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms. Data were analysed for publication characteristics, the compounds or herbal plants investigated, and their effects on the virus. A total of 37 articles with 242 citations were identified, demonstrating a steady increase in research activity since the first study in 2011, peaking in 2023 with 21 publications and 114 citations. The majority of studies originated from Southeast Asian countries. In terms of study design, most investigations were in silico (n = 31, 84%), followed by in vitro studies (n = 4, 11%), with no in vivo or clinical interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of in silico evidence, further laboratory and animal studies are imperative for translating these insights into clinical applications. The comprehensive library of compounds gathered through this research provides a valuable resource to facilitate this crucial next step in the development of herbal interventions against Mpox.

Keywords

Mpox - monkeypox virus - phytotherapy - evidence gaps - herbal medicine - natural product

Supporting Information

    The search strategy, reasons for excluding articles on the full-text level, publication and citation trends, a detailed list of eligible studies and natural compounds, and the association of keywords in the literature are available as supporting information.

  • Ergänzendes Material


Publikationsverlauf

Eingereicht: 26. Dezember 2024

Angenommen: 10. März 2025

Accepted Manuscript online:
17. März 2025

Artikel online veröffentlicht:
25. März 2025

© 2025. Thieme. All rights reserved.

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  • References

  • 1 Laurenson-Schafer H, Sklenovská N, Hoxha A, Kerr SM, Ndumbi P, Fitzner J, Almiron M, de Sousa LA, Briand S, Cenciarelli O, Colombe S, Doherty M, Fall IS, García-Calavaro C, Haussig JM, Kato M, Mahamud AR, Morgan OW, Nabeth P, Naiene JD, Navegantes WA, Ogundiran O, Okot C, Pebody R, Matsui T, Ramírez HL, Smallwood C, Tasigchana RFP, Vaughan AM, Williams GS, WHO mpox Surveillance and Analytics team. Mala PO, Lewis RF, Pavlin BI, le Polain de Waroux O. Description of the first global outbreak of mpox: An analysis of global surveillance data. Lancet Glob Health 2023; 11: e1012
    Suche in Google Scholar
  • 2 Ghebreyesus TA. Evolving Epidemiology of Mpox in Africa in 2024. N Engl J Med 2025; 392: 714-716
    Suche in Google Scholar
  • 3 Bangwen E, Diavita R, De Vos E, Vakaniaki EH, Nundu SS, Mutombo A, Mulangu F, Abedi AA, Malembi E, Kalonji T, Kacita C, Kinganda-Lusamaki E, Wawina-Bokalanga T, Kremer C, Brosius I, Van Dijck C, Bottieau E, Vercauteren K, Amuri-Aziza A, Makangara-Cigolo JC, Muyamuna E, Pukuta E, Nguete B, Kaba D, Kabamba J, Hughes CM, Tshiani-Mbaya O, Rimoin AW, Hoff NA, Kindrachuk J, Hens N, Peeters M, Low N, McCollum AM, Shongo R, Mukadi-Bamuleka D, Muyembe-Tamfum JJ, Ahuka-Mundeke S, Liesenborghs L, Mbala-Kingebeni P. Suspected and confirmed mpox cases in DR Congo: A retrospective analysis of national epidemiological and laboratory surveillance data, 2010–23. Lancet 2025; 405: 408-419
    Suche in Google Scholar
  • 4 Ndembi N, Folayan MO, Ngongo N, Ntoumi F, Ogoina D, El Rabbat M, Okwo-Bele JM, Kaseya J. Mpox outbreaks in Africa constitute a public health emergency of continental security. Lancet Glob Health 2024; 12: E1577-E1579
    Suche in Google Scholar
  • 5 Ndembi N, Folayan MO, Komakech A, Mercy K, Tessema S, Mbala-Kingebeni P, Ngandu C, Ngongo N, Kaseya J, Abdool Karim SS. Evolving Epidemiology of Mpox in Africa in 2024. N Engl J Med 2025; 392: 666-676
    Suche in Google Scholar
  • 6 Lum FM, Torres-Ruesta A, Tay MZ, Lin RTP, Lye DC, Rénia L, Ng LFP. Monkeypox: Disease epidemiology, host immunity and clinical interventions. Nat Rev Immunol 2022; 22: 597-613
    Suche in Google Scholar
  • 7 Titanji BK, Hazra A, Zucker J. Mpox clinical presentation, diagnostic approaches, and treatment strategies: A review. JAMA 2024; 332: 1652-1662
    Suche in Google Scholar
  • 8 Mudhasani RR, Golden JW, Adam GC, Hartingh TJ, Kota KP, Ordonez D, Quackenbush CR, Tran JP, Cline C, Williams JA, Zeng X, Olsen DB, Lieberman LA, Boyce C, Ginnetti A, Meinig JM, Panchal RG, Mucker EM. Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease. Microbiol Spectr 2024; 12: e03586-23
    Suche in Google Scholar
  • 9 Newman DJ, Cragg GM. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod 2020; 83: 770-803
    Suche in Google Scholar
  • 10 Seyhan AA. Lost in translation: The valley of death across preclinical and clinical divide – identification of problems and overcoming obstacles. Transl Med Commun 2019; 4: 18
    Suche in Google Scholar