Synthesis of Diarylmethanes by Cobalt-Catalyzed Reductive Cross-Coupling via Csp3-S Bond Activation

Various diarylmethane derivatives were synthesized by Co-catalyzed cross-electrophilic coupling of benzyl sulfonium salts with various aryl bromides in moderate to good yields. This simple protocol exhibited good tolerance for various functional groups. We demonstrated that low valent cobalt was able to activate both aryl halides and C-S bond from stable benzyl sulfonium salts, readily available from alcohols. Preliminary mechanistic studies suggested the involvement of benzyl radicals generated from C-S bond cleavage through a single electron transfer.

Publikationsverlauf

Eingereicht: 28. März 2025

Angenommen nach Revision: 29. April 2025

Accepted Manuscript online:
29. April 2025