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Planta Med
DOI: 10.1055/a-2627-4183
DOI: 10.1055/a-2627-4183
Reviews
Plant-derived Bioactive Substances with Anti-rheumatoid Arthritis Properties
Authors
This research was funded by the National Natural Science Foundation of China, grant number 31800688, China Scholarship Council, grant number No. 202406800020, the Foundation of Liaoning Educational Committee of China, grant number JYTMS20230765, the Science and Technology Project of Department of Science & Technology of Liaoning province of China, grant number 2024-MSLH-185, the Shenyang Youth Science and Technology Innovation Project, grant number RC220177, and the Screening of small-molecule tumor suppression compounds project, grant number SDUZHHT (2022) 2448 to Zhe Yang, as well as the Foundation of Liaoning Educational Committee of China, grant number LJ232410164021 to Huiyan Zhou and the Science and Technology Project of Hunan Province, grant number 2023JJ40882 to Jiong Li.
Abstract
Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by the accumulation of synovial fluid in joints, synovial inflammation, and cartilage damage. With the development of the disease, it may result in joint deformity, which affects the normal joint function of patients and seriously endangers peopleʼs life and health. According to statistics, the incidence of rheumatoid arthritis increases with age. However, there is currently no drug that can completely cure rheumatoid arthritis; only through certain drugs and measures can the progression of the disease be delayed. Plant-derived bioactive substances have garnered extensive research attention for their therapeutic potential in treating various diseases. Studies have shown that plant-derived bioactive substances play an important role in preventing rheumatoid arthritis. This review comprehensively and systematically evaluates plant-derived bioactive substances with anti-arthritic properties, specifically focusing on bioactive substances including flavonoids, polyphenols, terpenes, alkaloids, phenols, quinones, and phenylpropanoids, and elucidates their mechanisms of action to provide reference for the prevention and treatment of rheumatoid arthritis.
Publication History
Received: 12 December 2024
Accepted after revision: 29 May 2025
Article published online:
04 November 2025
© 2025. Thieme. All rights reserved.
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