Synthesis of Symmetric and P-chiral Self-assembling Pyridone-based Phosphorus Ligands

6-(Diphenylphosphino)pyridin-2(1H)-one (6-DPPon) is a unique ligand that can self-assemble in transition metal complexes. This self-assembly is achieved through hydrogen bonding interactions that mimic a bidentate coordination sphere. This enables high selectivity in catalytic transformations while ensuring sufficient flexibility for high catalytic activity. As a consequence, there is considerable interest in preparing derivatives of 6-DPPon and optimizing their synthesis. Herein, we present a comprehensive overview of the preparation methods for self-assembling pyridone-based phosphorus ligands. Nineteen pyridone ligands were prepared using electrophilic and nucleophilic routes, including eleven P-chiral ligands.

Publication History

Received: 17 June 2025

Accepted after revision: 03 August 2025

Accepted Manuscript online:
03 August 2025