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DOI: 10.1055/a-2675-4094
Synpacts

Recent Progress in Enantioselective Synthesis of γ-Lactams Bearing Chiral α-Quaternary Carbons

Yanan Sun
1   State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China (Ringgold ID: RIN12538)
,
Weiwei Xu
1   State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China (Ringgold ID: RIN12538)
,
Mengchun Ye
1   State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China (Ringgold ID: RIN12538)
2   Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, China (Ringgold ID: RIN12538)
› Author Affiliations
Supported by: the Haihe Laboratory of Sustainable Chemical Transformations and “Frontiers Science Center for New Organic Matter”, Nankai University 63181206
Supported by: National Natural Science Foundation of China 22188101,22325103
Supported by: Fundamental Research Funds for the Central Universities 63241529
Supported by: Key R&D Program of China 2022YFA1504300
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The enantioselective construction of γ-lactams bearing chiral α-quaternary carbons represents a significant challenge in organic synthesis due to steric and stereoelectronic constraints. This Synpact highlights recent advances in two complementary strategies: (1) ring decoration of preformed γ-lactams via asymmetric functionalization, and (2) ring construction through transition metal-catalyzed carbonylative cyclization. Emphasis is placed on emerging methods utilizing inert C(O)–H/CN precursors, with a analysis of recent advances, current limitations and future directions.



Publication History

Received: 03 June 2025

Accepted after revision: 03 August 2025

Accepted Manuscript online:
03 August 2025

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