Synlett
DOI: 10.1055/a-2675-4185
Letter

Synthesis of 2-arylquinoxalines from sulfoxonium ylides in the absence of sacrificial electrophile and base

Khanh T. N. Ong
1   VNU-HCM Key Laboratory for Advanced Materials and Structures, Vietnam National University Ho Chi Minh City Ho Chi Minh City University of Technology, Ho Chi Minh City, Viet Nam (Ringgold ID: RIN117295)
,
Khanh T. M. Le
1   VNU-HCM Key Laboratory for Advanced Materials and Structures, Vietnam National University Ho Chi Minh City Ho Chi Minh City University of Technology, Ho Chi Minh City, Viet Nam (Ringgold ID: RIN117295)
,
Anh T. Nguyen
1   VNU-HCM Key Laboratory for Advanced Materials and Structures, Vietnam National University Ho Chi Minh City Ho Chi Minh City University of Technology, Ho Chi Minh City, Viet Nam (Ringgold ID: RIN117295)
,
1   VNU-HCM Key Laboratory for Advanced Materials and Structures, Vietnam National University Ho Chi Minh City Ho Chi Minh City University of Technology, Ho Chi Minh City, Viet Nam (Ringgold ID: RIN117295)
› Author Affiliations
Preview

We report a method for annulation of 1,2-phenylenediamines and aryl sulfoxonium ylides to yield 2-arylquinoxalines. Known conditions often require sacrificial electrophiles, an oxidative solvent (i.e., DMSO), and an overstoichiometric amount of base. Herein conditions including the use of the catalytic amount of Bu4NI and m-xylene solvent to facilitate the formation of 2-arylquinoxalines in good to excellent yields have been developed. Functionalities including halogens, protected phenol, secondary amine groups were tolerant.



Publication History

Received: 02 June 2025

Accepted after revision: 03 August 2025

Accepted Manuscript online:
04 August 2025

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